Results 111 to 120 of about 11,342,017 (299)

Atrial natriuretic peptide signaling co-regulates lipid metabolism and ventricular conduction system gene expression in the embryonic heart

iScience
Summary: It has been shown that atrial natriuretic peptide (ANP) and its high affinity receptor (NPRA) are involved in the formation of ventricular conduction system (VCS). Inherited genetic variants in fatty acid oxidation (FAO) genes are known to cause
Abhishek Mishra, Mahtab Tavasoli, Stanislav Sokolenko, Christopher R. McMaster, Kishore B.S. Pasumarthi   +4 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Systems biology of coagulation [PDF]

Journal of Thrombosis and Haemostasis, 2013
Accurate computer simulation of blood function can inform drug target selection, patient-specific dosing, clinical trial design, biomedical device design, as well as the scoring of patient-specific disease risk and severity. These large-scale simulations rely on hundreds of independently measured physical parameters and kinetic rate constants. However,
openaire   +2 more sources

Bridging the gaps in systems biology [PDF]

, 2014
International audienceSystems biology aims at creating mathematical models, i.e., computational reconstructions of biological systems and processes that will result in a new level of understanding-the elucidation of the basic and presumably conserved ...
Stelling, J., Mendes, Pedro, Przulj, N., Stoma, S.,, Raue, A., Krantz, Marcus, Nelander, Sven, Almquist, Joachim,, Zecchina, R.,, Cvijovic, Marija,, Tobin, F.,, Krantz, M., Wodke, Judith A. H., Stelling, Joerg, Przulj, Natasa, Pagnani, Andrea, Pagnani, A.,, Tobin, F., Stoma, S., Wodke, Judith, Hagmar, Jonas,, Nielsen, Jens B.,, Zecchina, Riccardo, Stelling, Jörg, Kaltenbach, H. M., Nelander, S., Raue, Andreas, Kaltenbach, H. M.,, Klipp, Edda, Nielsen, Jens B,, Nielsen, Jens B., Wodke, J. A. H.,, Pagnani, A., Nelander, S.,, Nielsen, Jens B, Raue, A.,, Kaltenbach, Hans-Michael, Kaltenbach, Hans‑michael, Krantz, Marcus,, Mendes, P.,, Nielsen, Jens, Tobin, Frank, Klipp, E., Jirstrand, Mats, Wodke, J. A. H., Hohmann, Stefan,, Nelander, Sven,, Stelling, J.,, Jirstrand, Mats,, Mendes, P., Almquist, Joachim, Przulj, N.,, Hagmar, Jonas, Hohmann, Stefan, Stoma, Szymon, Cvijovic, Marija, Klipp, Edda,, Zecchina, R.   +57 more
core   +1 more source

Systems immunology: When systems biology meets immunology

Frontiers in Immunology
The immune system is an intricate network of cells, proteins, and signaling pathways that coordinate protective responses and, when dysregulated, drive immune−related diseases.
Lucía Alfonso-González, Lucía Alfonso-González, Francisco J. Fernández, M. Cristina Vega   +3 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Low dimensionality of phenotypic space as an emergent property of coordinated teams in biological regulatory networks

iScience
Summary: Cell-fate decisions involve coordinated genome-wide expression changes, typically leading to a limited number of phenotypes. Although often modeled as simple toggle switches, these rather simplistic representations often disregard the complexity
Kishore Hari, Pradyumna Harlapur, Aashna Saxena, Kushal Haldar, Aishwarya Girish, Tanisha Malpani, Herbert Levine, Mohit Kumar Jolly   +7 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Systems Biology Part 1

, 2017
Week 7: Systems Biology and Big Data 7.2 Systems Biology Systems Biology Lecture Part 1Demystifying Biomedical Big Data BIOX-201 ...
Haddad, Bassem, Gusev, Yuriy, McGarvey, Peter   +2 more
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source