Results 171 to 180 of about 11,342,017 (299)

Innovations 2023 dans le Secteur des Sciences de la Santé UCLouvain/Woluwé : « Systems Biology Core Facility »

L’évolution technologique dans l’analyse « omique » non-biaisée d’échantillons biologiques, combinée à un phénotypage clinique rigoureux permet d’affiner la compréhension de la physiopathologie de maladies complexes. Cette approche holistique utilise des
Balligand, Jean-Luc, Groupe Systems Biology   +1 more
core  

Beyond static biomarkers: systems biology and AI for decoding cancer dynamics. [PDF]

Front Syst Biol
Dutta S, Goli A.
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Bioinformatics and Systems Biology

BioTechniques, 2009
Lynne Lederman
doaj   +1 more source

Systems biology of yeast metabolism. [PDF]

FEMS Yeast Res
Nielsen J.
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The cell cloud: Adopting systems biology concepts in the era of single-cell immunology. [PDF]

PLoS Biol
Shay T, Benoist CO, Grieshaber-Bouyer R.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Cancer as a System Failure

Cancer Informatics, 2007
Igor Jurisica, Dennis Wigle
doaj  

Omics technologies in aquafeed: unlocking the black box towards systems biology. [PDF]

Funct Integr Genomics
Öz M, Üstüner E.
europepmc   +1 more source