Results 221 to 230 of about 2,989,026 (346)

Challenges and opportunities in systems biology education. [PDF]

Endocr Relat Cancer
Didier J, Croce S, Bayoumi S, Valceschini E, Escoffier H, Gonzalez E, Kishk A, Badkas A, De Landtsheer S, Sauter T.   +9 more
europepmc   +1 more source

Systems biology approaches to understand the role of auxin in root growth and development

, 2014
Tatsuaki Goh, Ute Voβ, Etienne Farcot, Malcolm J. Bennett, Anthony Bishopp   +4 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Unravelling the Complexity of Sarcopenia Through a Systems Biology Approach. [PDF]

Int J Mol Sci
Ceyhan AB, Altay O, Zhang C, Temel SG, Turkez H, Mardinoglu A.   +5 more
europepmc   +1 more source

Accelerating cancer systems biology research through Semantic Web technology

, 2012
Zhihui Wang, Jonathan Sagotsky, Thomas J. Taylor, Patrick Shironoshita, Thomas S. Deisboeck   +4 more
openalex   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Transcriptomic signatures in Gaucher disease subtypes: A systems biology perspective. [PDF]

Mol Genet Metab Rep
Elahimanesh M, Ganjali R, Najafi M.
europepmc   +1 more source

Targeted Systems Biology Profiling of Tomato Fruit Reveals Coordination of the Yang Cycle and a Distinct Regulation of Ethylene Biosynthesis during Postclimacteric Ripening       [PDF]

, 2012
Bram Van de Poel, Inge Bulens, Aikaterina Markoula, Maarten Hertog, Rozemarijn Dreesen, Markus Wirtz, Sandy Vandoninck, Yasmin Oppermann, J. Keulemans, Rüdiger Hell, Etienne Waelkens, M.P. De Proft, Margret Sauter, Bart Nicolaı̈, Annemie Geeraerd   +14 more
openalex   +1 more source

Systems Biology of Cyanobacteria for Investigating Light Adaptive Mechanisms

, 2022
Hiroshi Shimizu, Yoshihiro Toya
openalex   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source