Results 261 to 270 of about 1,150,837 (304)

Reframing type 1 diabetes through the endocannabinoidome-microbiota axis: a systems biology perspective. [PDF]

Front Endocrinol (Lausanne)
Łukowski W.
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Investigation of the relationship between chronic hepatitis B and tuberculosis using bioinformatics and systems biology approaches. [PDF]

Front Med (Lausanne)
He J, Zhou X, Zhang D, Cai Y, Pan H, Huang T, He F.   +6 more
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Leveraging public AI tools to explore systems biology resources in mathematical modeling. [PDF]

NPJ Syst Biol Appl
Kannan M, Bridgewater G, Zhang M, Blinov ML.   +3 more
europepmc   +1 more source

Gram-negative bacteria activate cellular pathways in plaque microenvironment; Systems biology approach. [PDF]

BMC Microbiol
Ganjali R, Elahimanesh M, Aghazadeh H, Najafi M.   +3 more
europepmc   +1 more source

Graph databases in systems biology: a systematic review. [PDF]

Brief Bioinform
Mazein I, Rougny A, Mazein A, Henkel R, Gütebier L, Michaelis L, Ostaszewski M, Schneider R, Satagopam V, Jensen LJ, Waltemath D, Wodke JAH, Balaur I.   +12 more
europepmc   +1 more source

A Systems Biology Approach Towards a Comprehensive Understanding of Ferroptosis. [PDF]

Int J Mol Sci
Arbatskiy M, Balandin D, Akberdin I, Churov A.   +3 more
europepmc   +1 more source

Advancements in multi-omics research to address challenges in Alzheimer's disease: a systems biology approach utilizing molecular biomarkers and innovative strategies. [PDF]

Front Aging Neurosci
Cardillo M, Katam K, Suravajhala P.
europepmc   +1 more source