Results 261 to 270 of about 25,508,313 (370)

Bioinformatics and Systems Biology

BioTechniques, 2009
Lynne Lederman
doaj   +1 more source

An integrated systems biology approach establishes arginine biosynthesis as a metabolic weakness in Candida albicans during host infection. [PDF]

Cell Commun Signal
Chakraborty S, Palanikumar I, Gune Y, Venkatesh KV, Raman K, Idicula-Thomas S.   +5 more
europepmc   +1 more source

Evolving a lingua franca and associated software infrastructure for computational systems biology: the Systems Biology Markup Language (SBML) project [PDF]

, 2004
Michael Hucka, Andrew Finney, John C. Doyle, Hiroaki Kitano, Ben Kovitz, Bruce E. Shapiro, Akira Funahashi, J. Matthews, B. Bornstein, Sarah Keating, Maria J. Schilstra   +10 more
openalex   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Deciphering dynamic antibiotics-microbiome-metabolome interactions in preterm infants using systems biology. [PDF]

iScience
Park SY, Lee YQ, Kim D, Sung DK, Kim KS, Lee JS, Cho JY, Lee W, Sung SI, Lee DY.   +9 more
europepmc   +1 more source

Applications of the Aurora parallel Prolog system to computational molecular biology

, 1993
Ewing Lusk, Shyam Mudambi, Ross Overbeek, Péter Szeredi   +3 more
openalex   +1 more source

CSB.DB: a comprehensive systems-biology database [PDF]

, 2004
Dirk Steinhauser, Björn Usadel, Alexander Luedemann, Oliver Thimm, Joachim Kopka   +4 more
openalex   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

The European Bioinformatics Institute's data resources: towards systems biology [PDF]

, 2004
Cath Brooksbank
openalex   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source