Results 271 to 280 of about 25,508,313 (370)

A systems biology approach to define SARS-CoV-2 correlates of protection. [PDF]

NPJ Vaccines
Brady C, Tipton T, Carnell O, Longet S, Gooch K, Hall Y, Salguero J, Tomic A, Carroll M.   +8 more
europepmc   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

High efficiency rare earth element bioleaching with systems biology guided engineering of Gluconobacter oxydans. [PDF]

Commun Biol
Schmitz AM, Pian B, Marecos S, Wu M, Holycross M, Gazel E, Reid MC, Barstow B.   +7 more
europepmc   +1 more source

Systems Biology: an information-theoretic-based thermo-statistical approach [PDF]

, 2004
Marcus V. Mesquita, Áurea R. Vasconcellos, Roberto Luzzi, S. Mascarenhas   +3 more
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Bioinformatics and systems biology to identify underlying common pathogenesis of diabetic kidney disease and stenosis of arteriovenous fistula. [PDF]

BMC Nephrol
Fu M, Liu F, Ren C, Wu Q, Xiao J, Wang Y, Zeng Y, Yang Y, Yan Y.   +8 more
europepmc   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

A Systems Biology Approach for Prioritizing ASD Genes in Large or Noisy Datasets. [PDF]

Int J Mol Sci
Remori V, Bondi H, Airoldi M, Pavinato L, Borini G, Carli D, Brusco A, Fasano M.   +7 more
europepmc   +1 more source

Plastic based microfluidic systems and their applications in biology. [PDF]

, 2002
Palaniappan Sethu
openalex  

A two-way interface between limited Systems Biology Markup Language and R [PDF]

, 2004
Tomas Radivoyevitch
openalex   +1 more source