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ACM SIGLOG News, 2017
The unequal race between technological and theoretical innovation in Computer Science has a mirror image in Systems Biology where the balance is even more biased toward the experimental side. The aim of Systems Biology is to produce a specification of natural systems, when artificial systems are usually already equipped with one
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The unequal race between technological and theoretical innovation in Computer Science has a mirror image in Systems Biology where the balance is even more biased toward the experimental side. The aim of Systems Biology is to produce a specification of natural systems, when artificial systems are usually already equipped with one
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Systems biology meets platelet biology
Blood, 2008In this issue of Blood , Purvis and colleagues describe a computational approach, employing 4 interlinked kinetic modules, to model platelet phosphoinositide and calcium regulation in resting platelets and after ADP-mediated P2Y1 purinergic receptor activation.
Berndt, Michael, Andrews, R.
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Introduction to systems biology
2007The developments in the molecular biosciences have made possible a shift to combined molecular and system-level approaches to biological research under the name of Systems Biology. It integrates many types of molecular knowledge, which can best be achieved by the synergistic use of models and experimental data.
Bruggeman, F.J. +3 more
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Metabolomics in Systems Biology
Annual Review of Plant Biology, 2003The primary aim of “omic” technologies is the nontargeted identification of all gene products (transcripts, proteins, and metabolites) present in a specific biological sample. By their nature, these technologies reveal unexpected properties of biological systems.
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The evolution of molecular biology into systems biology
Nature Biotechnology, 2004Systems analysis has historically been performed in many areas of biology, including ecology, developmental biology and immunology. More recently, the genomics revolution has catapulted molecular biology into the realm of systems biology. In unicellular organisms and well-defined cell lines of higher organisms, systems approaches are making definitive ...
Westerhoff, H.V., Palsson, B.O.
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2023
The application of mathematical and computational analysis, together with the modelling of biological and physiological processes, is transforming our understanding of the pathophysiology of complex diseases. This systems biology approach incorporates large amounts of genomic, transcriptomic, proteomic, metabolomic, breathomic, metagenomic and imaging ...
Kermani, NZ +4 more
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The application of mathematical and computational analysis, together with the modelling of biological and physiological processes, is transforming our understanding of the pathophysiology of complex diseases. This systems biology approach incorporates large amounts of genomic, transcriptomic, proteomic, metabolomic, breathomic, metagenomic and imaging ...
Kermani, NZ +4 more
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Annals of the New York Academy of Sciences, 2005
Abstract: As more detailed molecular information accumulates on the biology of the heart and other complex systems in health and disease, the need for new integrative analyses and tools is growing. Systems biology and bioengineering seek to use high‐throughput technologies and integrative computational analysis to construct networks of the ...
Andrew D, McCulloch +1 more
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Abstract: As more detailed molecular information accumulates on the biology of the heart and other complex systems in health and disease, the need for new integrative analyses and tools is growing. Systems biology and bioengineering seek to use high‐throughput technologies and integrative computational analysis to construct networks of the ...
Andrew D, McCulloch +1 more
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Communications of the ACM, 2009
The convergence of CS and biology will serve both disciplines, providing each with greater power and relevance.
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The convergence of CS and biology will serve both disciplines, providing each with greater power and relevance.
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2010
Cancer is a complex and heterogeneous disease, not only at a genetic and biochemical level, but also at a tissue, organism, and population level. Multiple data streams, from reductionist biochemistry in vitro to high-throughput "-omics" from clinical material, have been generated with the hope that they encode useful information about phenotype and ...
Dana, Faratian +4 more
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Cancer is a complex and heterogeneous disease, not only at a genetic and biochemical level, but also at a tissue, organism, and population level. Multiple data streams, from reductionist biochemistry in vitro to high-throughput "-omics" from clinical material, have been generated with the hope that they encode useful information about phenotype and ...
Dana, Faratian +4 more
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Nature Methods, 2006
A web and print Focus on systems biology from Nature Publishing Group provides a practical introduction to a field that for all its promise still has many skeptics.
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A web and print Focus on systems biology from Nature Publishing Group provides a practical introduction to a field that for all its promise still has many skeptics.
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