Results 91 to 100 of about 4,654,755 (329)

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Systems engineering and its application to educational programs of the Tomsk Polytechnic University

Известия Томского политехнического университета: Инжиниринг георесурсов, 2019
The urgency of the work is caused by the need to develop Russian engineering education in the field of systems engineering caused by industry demand for specialists in developing complex heterogeneous systems.
P. S. Chubik, N. G. Markov, E. A. Miroshnichenko, T. S. Petrovskaya   +3 more
doaj  

UCTM—An Ambidextrous Service Innovation Framework—A Bottom-Up Approach to Combine Human- and Technology-Centered Service Design

Systems, 2019
Digital innovation is a key success factor for business enterprises and organizations concerned with public safety. Increasingly shorter technology cycles produce a stream of highly promising gadgets and smart devices and this innovative provision opens ...
Wolfgang Vorraber, Dietmar Neubacher, Birgit Moesl, Julia Brugger, Sigmar Stadlmeier, Siegfried Voessner   +5 more
doaj   +1 more source

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

On the engineering of systems of systems: key challenges for the requirements engineering community! [PDF]

Software intensive systems of the future will be ultra large-scale systems of systems. Systems of Systems Engineering focuses on the interoperation of many independent, self-contained constituent systems to achieve a global need. The scale and complexity
Ncube, Cornelius
core  

Sensor & instrumentation system : series 2 [PDF]

, 2017
This book is an introduction to a number of the topics in sensor and instrumentation systems. Many of the topics describe the design experiments and system measurement especially in sensor applications.

core  

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Algebraic Expressions for Complex Deep Learning Systems Modeling and Analysis

IEEE Access
Many modern Deep Learning (DL) systems have achieved impressive state-of-the-art results by combining individual sub-systems, including foundation models, to form increasingly more complex DL systems.
Rhandall Valdez-Yepez, Bryan V. Piguave, Jennifer C. Pita, Andres G. Abad   +3 more
doaj   +1 more source

Engineering Trust-based Software Intensive Systems

, 2004
of a keynote speech given at the Strategic Research Workshop on Engineering Software Intensive ...
Sassone, V.
core  

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source