Results 71 to 80 of about 1,053,739 (267)

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Risk Analysis of Artificial Intelligence in Medicine with a Multilayer Concept of System Order

open access: yesSystems
Artificial intelligence (AI) is advancing across technology domains including healthcare, commerce, the economy, the environment, cybersecurity, transportation, etc. AI will transform healthcare systems, bringing profound changes to diagnosis, treatment,
Negin Moghadasi   +7 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A Case-Study-Based Comparative Evaluation of Functional Analysis Paradigms in Aircraft System Design

open access: yesApplied Sciences
Functional analysis plays a critical role in early-stage aircraft system design by defining system functions that guide downstream architectural development and verification.
Haomin Li   +3 more
doaj   +1 more source

Knowledge Phenomenology Research on Disruptive Innovative Design of Future Industries [PDF]

open access: yes中国工程科学
Innovative design serves as both a precursor and a foundational component in advancing future industries. It is also a key driver in fostering new quality productive forces.
Jiang Xu, Haoxiang Qu
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

An Interpretable Socio-Technical Decision Support System for Bi-Objective Urban Distribution Center Location: Adaptive Optimization Supervised by a Large Language Model

open access: yesSystems
Urban e-commerce fulfillment involves multiple operational stages, including goods receipt, storage, picking, packaging, dispatching, and delivery to customers.
Jiaxiang Hu, Qi Chen
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

The Broken Promise of Autonomy: A Systems Engineering Critique of the DAO Ecosystem

open access: yesIEEE Access
The nomenclature of Decentralized Autonomous Organizations (DAOs) implies a capability for autonomous operation that remains theoretically undefined and empirically unverified.
Kolja Sahm, George M. Giaglis
doaj   +1 more source

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