Results 51 to 60 of about 13,668,708 (244)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Application of model based systems engineering methods to development of combat system architectures [PDF]
, 2009 Navy acquisition activities frequently produce combat system architectures based on existing systems rather than stakeholder requirements. This approach limits software component reuse which, in turn, limits potential application to other platforms ...
Hoang, Tuyen +26 more
core +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Design Catalogues: An Efficient Search Approach for Improved Flexibility in Engineering Systems Design [PDF]
, 2013 23rd Annual International Symposium of the International Council on Systems Engineering, INCOSE 20131398 ...
Cardin, Michel-Alexandre +3 more
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Engineering systems integration: theory, metrics, and methods
, 2012 The first book to address the underlying premises of systems integration and how to exposit them into a practical and productive manner, this book prepares systems managers and systems engineers to consider their decisions in light of systems integration
Langford, Gary O., Langford, Gary O
core
International Conference on Industry, Engineering, and Management Systems (2004 : Cocoa Beach, Fla.)
, 2004 Digitized and published in SOAR: Shocker Open Access Repository by Wichita State University Libraries Technical Services, May 2022.The IEMS'04 conference committee: California State University Stanislaus Department of Management, Operations, and ...
International Conference on Industry, Engineering, and Management Systems
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source