Results 31 to 40 of about 1,468,527 (267)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Submarine combat systems engineering project capstone project [PDF]

open access: yes, 2011
The Combat Control System (CCS) construct developed using a systems engineering approach, when implemented, will provide significantly increased levels of automation.
Becker, John   +5 more
core  

International Conference on Industry, Engineering, and Management Systems 2017

open access: yes, 2017
Published in SOAR: Shocker Open Access Repository by Wichita State University Libraries Technical Services, May 2022.The IEMS'17 conference committee: Nael Aly (Conference Co-Chair); Ahmad Elshennawy (Conference Co-Chair); Gamal Waheba (Program Chair ...
International Conference on Industry, Engineering, and Management Systems
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

International Conference on Industry, Engineering, and Management Systems 2019

open access: yes, 2019
Published in SOAR: Shocker Open Access Repository by Wichita State University Libraries Technical Services, May 2022.The IEMS'19 conference committee: Gamal Weheba (Conference Chair); Hesham Mahgoub (Conference Co-Chair); Sandra Furterer (Program Chair);
International Conference on Industry, Engineering, and Management Systems
core   +1 more source

On the engineering of systems of systems: Key challenges for the Requirements Engineering community [PDF]

open access: yes2011 Workshop on Requirements Engineering for Systems, Services and Systems-of-Systems, 2011
Software intensive systems of the future will be ultra large-scale systems of systems. Systems of Systems Engineering focuses on the interoperation of many independent, self-contained constituent systems to achieve a global need. The scale and complexity of systems of systems possess unique challenges for the Requirements Engineering community. Current
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

UTILIZING A MODEL-BASED SYSTEMS ENGINEERING APPROACH TO DEVELOP A COMBAT SYSTEM PRODUCT LINE [PDF]

open access: yes, 2018
Current U.S. Navy combat system suites are ship class dependent. There are a variety of configurations that include sensors, weapons, and system interfaces to accomplish similar goals.
Hall, Robert
core  

Industrial and Systems Engineering Review - Guest Editorial

open access: yes, 2017
This special issue of the Industrial and Systems Engineering Review (ISER) represents a collection of exemplary undergraduate research, engineering, and analysis.
Evangelista, Paul
core   +1 more source

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