Results 41 to 50 of about 1,053,739 (267)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Development of a Functional and Logical Reference System Architecture in Automotive Engineering
SystemsThe automobile is evolving from a mechanically dominated to a cyber-physical, software-defined system. Future complex functionalities, such as autonomous driving, require multidisciplinary, interconnected systems.
Jonas Krog +3 more
doaj +1 more source
On the engineering of systems of systems: Key challenges for the Requirements Engineering community [PDF]
2011 Workshop on Requirements Engineering for Systems, Services and Systems-of-Systems, 2011 Software intensive systems of the future will be ultra large-scale systems of systems. Systems of Systems Engineering focuses on the interoperation of many independent, self-contained constituent systems to achieve a global need. The scale and complexity of systems of systems possess unique challenges for the Requirements Engineering community. Current
openaire +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
MachinesThis paper presents a novel integration of Systems Engineering (SE) methodologies and Industry 4.0 (I4.0) technologies in the design of robotic systems, focusing on enhancing underwater robotic missions.
Jaime Alonso Restrepo-Carmona +5 more
doaj +1 more source
Comparative Evaluation of Software Composition Analysis Tools in Context of Technical Debt Reduction [PDF]
المجلة الدولية للسياسات العامة في مصريُستخدم مصطلح "الدين الفني" في هندسة البرمجيات لوصف الحلول التقنية التي قد تكون عملية على المدى القصير ولكن لها عواقب ضارة على المدى الطويل. تركز الدراسة على تقييم أدوات تحليل تكوين البرمجيات (SCA) Software Composition Analysis في سياق تقليل الديون ...
ندى مصطفى علي +2 more
doaj +1 more source