Results 21 to 30 of about 1,468,527 (267)

International Conference on Industry, Engineering, and Management Systems (2004 : Cocoa Beach, Fla.)

, 2004
Digitized and published in SOAR: Shocker Open Access Repository by Wichita State University Libraries Technical Services, May 2022.The IEMS'04 conference committee: California State University Stanislaus Department of Management, Operations, and ...
International Conference on Industry, Engineering, and Management Systems
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Engineering Systems Multiple-Domain Matrix: An organizing framework for modeling large-scale complex systems

, 2009
The scope and complexity of engineered systems are ever-increasing as burgeoning global markets, unprecedented technological capabilities, rising consumer expectations, and ever-changing social requirements present difficult design challenges that often ...
de Neufville, Richard, Rhodes, Donna H., Donna H. Rhodes, Hastings, Daniel E., Daniel E. Hastings, Jason E. Bartolomei, Richard de Neufville, Bartolomei, Jason E.   +7 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Design Catalogues: An Efficient Search Approach for Improved Flexibility in Engineering Systems Design [PDF]

, 2013
23rd Annual International Symposium of the International Council on Systems Engineering, INCOSE 20131398 ...
Cardin, Michel-Alexandre, de Neufville, Richard, Richard de Neufville, Michel‐Alexandre Cardin   +3 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

MULTIAGENT SYSTEMS ENGINEERING [PDF]

International Journal of Software Engineering and Knowledge Engineering, 2001
This paper describes the Multiagent Systems Engineering (MaSE) methodology. MaSE is a general purpose, methodology for developing heterogeneous multiagent systems. MaSE uses a number of graphically based models to describe system goals, behaviors, agent types, and agent communication interfaces.
Scott A. DeLoach, Mark F. Wood, Clint H. Sparkman   +2 more
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source