Results 61 to 70 of about 1,053,739 (267)
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Applied SciencesHistoric Building Information Modelling (HBIM) is the application of BIM, an information management and modelling process, to cultural heritage (CH) assets.
Lucy J. Lovell +2 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Вестник Донского государственного технического университета, 2018 The design techniques of integrated information systems development aimed at the life cycle support are reviewed. Cases of the CALS-technologies and systems engineering for building some typical models are considered. These models can be used for typical
Dmitry V. DUDKIN
doaj
AerospaceThis paper introduces a power-driven systems engineering methodology for the early-phase design of highly miniaturized satellites: PlanarSats. We derive an analytical framework linking power requirements, contingency policies, solar-cell performance, and
Mehmet Şevket Uludağ +1 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Power Contingency/Margin Methodology and Operational Envelope Analysis for PlanarSats
AerospaceThis paper presents a power-centric systems-engineering approach for PlanarSats and for atto-, and femto-class spacecraft where surface-limited power dominates design.
Mehmet Şevket Uludağ +1 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Semantic Priority Navigation for Energy-Aware Mining Robots
SystemsAutonomous navigation in subterranean mines is hindered by deformable terrain, dust-laden visibility, and densely packed, safety-critical machinery. We propose a systems-oriented navigation framework that embeds semantic priorities into reactive planning
Claudio Urrea +2 more
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source