Results 141 to 150 of about 25,134,561 (338)

Complex Engineering Systems and Systems Engineering [PDF]

2018 IEEE 23rd International Conference on Emerging Technologies and Factory Automation (ETFA), 2018
openaire   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Systems engineering-based framework of process risks in perioperative medication delivery. [PDF]

Br J Anaesth, 2022
Coppola SM, Neyens DM, Catchpole K, Gurses AP, Osei P, Biro JM, Alfred M, Rucks M, Tobin CD, Jaruzal C, Abernathy JH, Operating Room System based Medication Administration error Reduction Team (OR SMART) Research Group.   +11 more
europepmc   +1 more source

FUEL CHARGING SYSTEM. HRT-CP Engineering Test T-11 and T-16

, 1956
R.E. Brooksbank
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

"We should be resourcing their liberation:" a qualitative formative study to guide introduction of a systems engineering intervention at a King County, WA juvenile detention center clinic. [PDF]

BMC Health Serv Res, 2023
Borges M, Schipper L, Gonzalez G, Goode S, Hersh D, Pham DQ, Kaplan B, Ronen K, Sherr K, Gimbel S.   +9 more
europepmc   +1 more source

Probabilistic analysis of large-scale engineering systems

, 2012
Jianjun Qin
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Entangled Autopoiesis: Reframing Psychotherapy and Neuroscience Through Cognitive Science and Systems Engineering. [PDF]

Brain Sci
Rad D, Maier M, Triff Z, Marcu R.
europepmc   +1 more source

Systems engineering analysis of diagnostic referral closed-loop processes. [PDF]

BMJ Open Qual, 2021
Nehls N, Yap TS, Salant T, Aronson M, Schiff G, Olbricht S, Reddy S, Sternberg SB, Anderson TS, Phillips RS, Benneyan JC.   +10 more
europepmc   +1 more source