Results 81 to 90 of about 4,654,755 (329)

Practitioner requirements for integrated Knowledge-Based Engineering in Product Lifecycle Management.

, 2008
The effective management of knowledge as capital is considered essential to the success of engineering product/service systems. As Knowledge Management (KM) and Product Lifecycle Management (PLM) practice gain industrial adoption, the question of ...
Bermell-Garcia, Pablo, Fan, Ip-Shing
core   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Ground-state Stabilization of Open Quantum Systems by Dissipation

, 2015
Control by dissipation, or environment engineering, constitutes an important methodology within quantum coherent control which was proposed to improve the robustness and scalability of quantum control systems.
James, Matthew R., Pan, Yu, Ugrinovskii, Valery   +2 more
core   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

OVERVIEW OF AUTOMATION METHODS OF SMALL AND MEDIUM ENGINEERING ENTERPRISES BASED ON CALS-TECHNOLOGIES AND SYSTEMS ENGINEERING APPROACH

Вестник Донского государственного технического университета, 2018
The design techniques of integrated information systems development aimed at the life cycle support are reviewed. Cases of the CALS-technologies and systems engineering for building some typical models are considered. These models can be used for typical
Dmitry V. DUDKIN
doaj  

Towards a Unified Modeling and Simulation Framework for Space Systems: Integrating Model-Based Systems Engineering with Open Source Multi-Domain Simulation Environments

Aerospace
The increasing complexity of modern space systems requires a more integrated and scalable approach to their design, analysis, and verification. Model-Based Systems Engineering (MBSE) has emerged as a powerful methodology for managing the complexity of ...
Serena Campioli, Giacomo Luccisano, Davide Ferretto, Fabrizio Stesina   +3 more
doaj   +1 more source

Embedded Software Design for Mechatronic Systems [PDF]

, 2003
This research project is motivated by the fact that nowadays it is impossible to separate control engineering from software engineering. Besides that both of them can be found in definitions of mechatronics, this project deals with exploitation and ...
Broenink, Jan F., Hilderink, Gerald H., Jovanovic, Dusko   +2 more
core   +1 more source

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Daniel Bachurski, Michael Hallek
wiley   +1 more source