Results 81 to 90 of about 25,134,561 (338)

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

OVERVIEW OF AUTOMATION METHODS OF SMALL AND MEDIUM ENGINEERING ENTERPRISES BASED ON CALS-TECHNOLOGIES AND SYSTEMS ENGINEERING APPROACH

open access: yesВестник Донского государственного технического университета, 2018
The design techniques of integrated information systems development aimed at the life cycle support are reviewed. Cases of the CALS-technologies and systems engineering for building some typical models are considered. These models can be used for typical
Dmitry V. DUDKIN
doaj  

Engaging the International Heritage Community to Validate End-User Requirements for Historic Building Information Modelling

open access: yesApplied Sciences
Historic Building Information Modelling (HBIM) is the application of BIM, an information management and modelling process, to cultural heritage (CH) assets.
Lucy J. Lovell   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

An Analytical Framework for Determining the Minimum Size of Highly Miniaturized Satellites: PlanarSats

open access: yesAerospace
This paper introduces a power-driven systems engineering methodology for the early-phase design of highly miniaturized satellites: PlanarSats. We derive an analytical framework linking power requirements, contingency policies, solar-cell performance, and
Mehmet Şevket Uludağ   +1 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

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