Results 81 to 90 of about 291,090 (273)

Deciphering host immunity to malaria using systems immunology

, 2020
A century of conceptual and technological advances in infectious disease research has changed the face of medicine. However, there remains a lack of effective interventions and a poor understanding of host immunity to the most significant and complex ...
Doolan, Denise L., Martha M. Cooper, Loiseau, Claire, Denise L. Doolan, Claire Loiseau, Cooper, Martha M.   +5 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Systems immunology reveals a linked IgG3–C4 response in patients with acute rheumatic fever

, 2020
Acute rheumatic fever (ARF) and chronic rheumatic heart disease (RHD) are autoimmune sequelae of a Group A streptococcal infection with significant global mortality and poorly understood pathogenesis.
Timothy KC Ho, Martin, William J, Amy W Chung, Tay, Mei Lin, Nigel J Wilson, Tritscheller, Susanne, Williamson, Deborah A, Cristin G Print, Gurney, Jason K, Jeremy M Raynes, Ho, Timothy Kc, Lorenz, Natalie, Alana L Whitcombe, Paulina Hanson‐Manful, Reuben McGregor, Raynes, Jeremy M, Wilson, Nigel J, Moreland, Nicole J, William J Martin, Michael G Baker, Jane R Oliver, Hanson-Manful, Paulina, Chung, Amy W, McGregor, Reuben, Susanne Tritscheller, Mei Lin Tay, Baker, Michael G, Deborah A Williamson, Oliver, Jane R, Natalie Lorenz, Nicole J Moreland, Jason K Gurney, Whitcombe, Alana L, Print, Cristin G   +33 more
core   +1 more source

Cytokines [PDF]

, 2020
The human immune system is a complicated biological network that employs a collection of cells, molecules, and proteins. Cytokines play an important role in regulating the innate and adaptive immune systems by different receptors and signaling pathways ...

core   +1 more source

Philosophy of immunology [PDF]

, 2020
Philosophy of immunology is a subfield of philosophy of biology dealing with ontological and epistemological issues related to the studies of the immune system.
Swiatczak, Bartlomiej, Tauber, Alfred I.
core   +1 more source

Co-regulation of innate and adaptive immune responses induced by ID93+GLA-SE vaccination in humans

Frontiers in Immunology
IntroductionDevelopment of an effective vaccine against tuberculosis is a critical step towards reducing the global burden of disease. A therapeutic vaccine might also reduce the high rate of TB recurrence and help address the challenges of drug ...
Andrew Fiore-Gartland, Himangi Srivastava, Aaron Seese, Tracey Day, Adam Penn-Nicholson, Angelique Kany Kany Luabeya, Nelita Du Plessis, Andre G. Loxton, Linda-Gail Bekker, Andreas Diacon, Gerhard Walzl, Zachary K. Sagawa, Steven G. Reed, Thomas J. Scriba, Mark Hatherill, Rhea Coler, Rhea Coler, Rhea Coler   +17 more
doaj   +1 more source

Diagnostic Profiling of the Human Public IgM Repertoire With Scalable Mimotope Libraries

Frontiers in Immunology, 2019
Specific antibody reactivities are routinely used as biomarkers, but the antibody repertoire reactivity (igome) profiles are still neglected. Here, we propose rationally designed peptide arrays as efficient probes for these system level biomarkers.
Anastas Pashov, Velizar Shivarov, Velizar Shivarov, Maya Hadzhieva, Victor Kostov, Victor Kostov, Dilyan Ferdinandov, Karen-Marie Heintz, Shina Pashova, Shina Pashova, Milena Todorova, Tchavdar Vassilev, Thomas Kieber-Emmons, Leonardo A. Meza-Zepeda, Eivind Hovig, Eivind Hovig   +15 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source