Results 161 to 170 of about 3,975,199 (305)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Beyond Compliance: Identifying High-Performance Models and Critical Success Factors for Integrated Management System Effectiveness (A Systematic Review)

Ianna Journal of Interdisciplinary Studies
Background: Organisations' interest in integrating management systems has emerged as a key strategy for improving organisational performance. Finding a model that fits the organisation's needs and optimises activities with the greatest possible benefit ...
Jesús Enrique Osorio Romero, Dina Luz Castro Páez, Braian López Ossa, Mabel Ibarra Luna   +3 more
doaj  

Techno-economic analysis for a 100% renewable hybrid energy systems integration in a research facility in Morocco. [PDF]

iScience
Choukri NE, Touili S, Azzaoui A, Alami Merrouni A.   +3 more
europepmc   +1 more source

Indicators and Measurement Tools for Health Systems Integration: A Knowledge Synthesis. [PDF]

Int J Integr Care, 2017
Suter E, Oelke ND, da Silva Lima MAD, Stiphout M, Janke R, Witt RR, Van Vliet-Brown C, Schill K, Rostami M, Hepp S, Birney A, Al-Roubaiai F, Marques GQ.   +12 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Potential benefits and human systems integration of parastronauts with bilateral vestibulopathy for a space mission. [PDF]

Front Neurol
Ramsburg CF, Wood SJ, Lackner JR, Moynihan S, Reschke MF, Denise P, Clément G.   +6 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Public Health Workforce Professional Development Analysis: A Human-Systems Integration for Healthy Communities. [PDF]

Int J Public Health
Osnat B, Orna BE, Tomasz B, Kasia C, Nadav D, Jascha N, Keren D, Mariusz D, Janas H, Lore L, Hagai L, Fiona M, Maureen M, Zohar M, Yehuda N, Leah OE, Robert O, Stephanie PB, Maya PR, Theodore T, Shira ZS, Paul B.   +21 more
europepmc   +1 more source

Highlights from the First Annual Spinal Navigation, Emerging Technologies and Systems Integration Meeting. [PDF]

Ann Transl Med, 2018
Drazin D, Grunert P, Hartl R, Polly D, Meyer B, Catchpole K, Laufer I, Sethi R, Perry T, Simon D, Wang M, Fisher C, Scribner M, White G, Tubbs RS, Oskouian RJ, Kim T, Johnson JP.   +17 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source