Results 131 to 140 of about 2,242,763 (316)

Impacts of site aridity on intra-annual radial variation of two alpine coniferous species in cold and dry ecosystems

Ecological Indicators
Climate change alters regional aridity and species composition in dryland ecosystems. However, the effect of varying aridity and species-specific responses on tree growth remains unclear. Here, we used high-resolution dendrometers to analyze the climatic
Junzhou Zhang, Xiaohua Gou, Yuetong Wang, Qipeng Sun, Junjun Liu, Fang Wang, Min Xu, Jiqin Yang, Patrick Fonti   +8 more
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Is a Field an Intelligent System?

, 2021
The majority of physicists take it for granted that the universe is made up of matter. In turn, matter is composed of atoms; atoms are made up of particles such as electrons, protons, neutrons, etc. Also, protons and neutrons are composed of quarks, etc. Furthermore, that everything in nature is governed by the known laws of physics and chemistry.
openaire   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

The Sustainability Imperative in Information Systems Research

, 2017
This paper reports on a panel discussion at the pre-ICIS 2015 Workshop on Green Information Systems on the current state and future perspectives of SIGGreen—the Association of Information Systems’ special interest group on green information systems—and ...
Bharati, Pratyush, Guzman, I, Albizri, A, Janet Toland, Lee, H, Butler, Tom, Karsten, Helena, Nigel Melville, Melville, Nigel, Fridgen, G, Karsten, H, Daniel Rush, Marie-Claude (Maric) Boudreau, Watts, Stephanie, Stephanie Watts, Kruse, Leona Chandra, Watson, RT, Lee, Habin, Gilbert Fridgen, Watson, Richard T., Fridgen, Gilbert, Boudreau, Maric, Seidel, Stefan, Habin Lee, Kruse, LC, Guzman, Indira, Toland, J, Rush, Daniel, Richard T. Watson, Abdullah Albizri, Bharati, P, Seidel, S, Leona Chandra Kruse, Boudreau, Marie-Claude (Maric), Rush, D, Albizri, Abdullah, Toland, Janet, Boudreau, MCM, Stefan Seidel, null null, Tom Butler, Butler, T, Helena Karsten, Pratyush Bharati, Watts, S, Melville, N, Indira Guzman   +46 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Using Monoscopic Multispectral Earth Observation Images to Predict Terrain Features With Deep Neural Networks

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
In the field of remote sensing and Earth observation, deep neural networks (DNNs) have established themselves as important tools for many different image analysis applications.
Kristoffer Langstad, Eleonora Jonasova Parelius, Stian Lovold, David Volgyes   +3 more
doaj   +1 more source

Field Robot and Sensing system [PDF]

Proceedings of International Conference on Artificial Life and Robotics, 2019
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The database of peptide medications for human deep-space missions demonstrates the potential for on-demand “Astropharmacy”

Frontiers in Space Technologies
With the advent of long-duration lunar and Martian space missions, health risks will increase significantly as astronauts will be exposed to prolonged periods of reduced gravity, elevated radiation levels, celestial dust, and isolated environments that ...
Rebecca C. Blum, Rebecca C. Blum, Dorra Omrani, Alina Kunitskaya, Alina Kunitskaya, Jessica E. Snyder, Jessica E. Snyder, Cynthia Bui, Philip M. Williams, David J. Loftus, Lynn J. Rothschild, Lynn J. Rothschild, Lynn J. Rothschild   +12 more
doaj   +1 more source