Results 111 to 120 of about 2,242,763 (316)

Runoff Losses in Nitrogen and Phosphorus From Paddy and Maize Cropping Systems: A Field Study in Dongjiang Basin, South China. [PDF]

Front Plant Sci, 2021
Zeng F, Zuo Z, Mo J, Chen C, Yang X, Wang J, Wang Y, Zhao Z, Chen T, Li Y, Zhang Z, Hu Z, Xu H.   +12 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Configurational innovation systems – Explaining the slow German heat transition

, 2019
In the field of sustainability transitions, temporality has recently received increased attention, specifically with regard to understanding acceleration of transitions.
Raven, R. P.J.M., Wesche, J. P., Negro, S. O., Dütschke, E., Hekkert, M. P., Innovation Studies, Dynamics of Innovation Systems   +6 more
core   +1 more source

Conductive Interference in Rapid Transit Signaling Systems: Volume II: Suggested Test Procedures

UM564/R5633Methods for detecting and quantifying the levels of conductive electromagnetic interference produced by solid state rapid transit propulsion equipment and for determining the susceptibility of signaling systems to these emissions are presented.
Holstrom, F. Ross, U.S. Department of Transportation. Research and Special Programs Administration. Transportation Systems Center, John A. Volpe National Transportation Systems Center (U.S.)   +2 more
core   +2 more sources

Oculometric biomarkers of visuomotor deficits in clinically asymptomatic patients with systemic lupus erythematosus undergoing long-term hydroxychloroquine treatment

Frontiers in Ophthalmology
IntroductionThis study examines a set of oculomotor measurements, or “oculometric” biomarkers, as potential early indicators of visual and visuomotor deficits due to retinal toxicity in asymptomatic Systemic Lupus Erythematosus (SLE) patients on long ...
Andrew R. Berneshawi, Kimia Seyedmadani, Kimia Seyedmadani, Rahul Goel, Rahul Goel, Mark R. Anderson, Mark R. Anderson, Terence L. Tyson, Yasmin M. Akay, Metin Akay, Loh-Shan B. Leung, Leland S. Stone   +11 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Radiant Systems Field Services Redesign Project

, 2010
Presented on May 5, 2010 from 6:00 PM – 8:00 PM in the Instructional Center, room 205 on the Georgia Tech campus.Best of Senior Design Spring 2010 Finalist Presentations.Runtime: 19:20 minutesThe team recommended Radiant Systems, the leading global ...
Weber, Mackenzie, Craig, Ian, Click, Josh, Kaylen, Kristina, Blakes, Dillon, Darnowsky, Randy, Feyereisen, Joel, Kent, Jesse   +7 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Understanding the processes of Information Systems deployment and evaluation: The challenges facing e-health

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Information Systems (IS) innovations in healthcare sector are seen as panacea to control burgeoning demand on healthcare resources and lack of streamlining ...
Sharma, Urvashi
core