Results 101 to 110 of about 2,242,763 (316)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Field scale tests of the modified moldboard plow

, 1991
In 1989-90 four trials were conducted in southwestern Ontario to study the effect of moldboard modifications on the field scale residue management potential of the moldboard plough.
Conservation Management Systems, A Division of Ecologistics Limited
core  

Direct free energy evaluation of classical and quantum many-body systems via field-theoretic simulation. [PDF]

Proc Natl Acad Sci U S A, 2022
Fredrickson GH, Delaney KT.
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Hospital-Based Mortality in Federal Capital Territory Hospitals-Nigeria, 2005- 2008

The Pan African Medical Journal, 2012
BACKGROUND: Cause-specific mortality data are important to monitor trends in mortality over time. Medical records provide reliable documentation of the causes of deaths occurring in hospitals.
Nykiconia Preacely, Oladayo Biya, Saheed Gidado, Halima Ayanleke, Mohammed Kida, Moses Akhimien, Aisha Abubakar, Ibrahim Kurmi, Ikeoluwapo Ajayi, Patrick Nguku, Henry Akpan   +10 more
doaj   +1 more source

Kinematic Loggers-Development of Rugged Sensors and Recovery Systems for Field Measurements of Stone Rolling Dynamics and Impact Accelerations during Floods. [PDF]

Sensors (Basel), 2022
Biggs H, Starr A, Smith B, de Lima S, Sykes J, Haddadchi A, Smart G, Hicks M.   +7 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Modeling and Simulation of Cyber-Physical Systems

, 2015
Cyber physical systems need to be effectively safe and their design requires a preliminary and carefull definition of functions, architectures and missions. Those tasks are carried out by implementing the Systems Engineering approach and related.actions,
Cala’, A., Schamai, W., Ferretto, Davide, Pessa, C., C. PESSA, Rooks, S., L. GREENBERG, Mitschke, A., Bachelor, G., CALA', AMBRA, Greenberg, L., W. SCHAMAI, A. MITSCHKE, S. ROOKS, G. BACHELOR, Brusa, Eugenio   +15 more
core  

Converged IP-over-standard ethernet progress control networks for hydrocarbon process automation applications controllers [PDF]

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The maturity level of Internet Protocol (IP) and the emergence of standard Ethernet interfaces of Hydrocarbon Process Automation Application (HPAA) present ...
Almadi, Soloman Moses
core  

Neighbour-induced changes in root exudation patterns of buckwheat results in altered root architecture of redroot pigweed

Scientific Reports
Roots are crucial in plant adaptation through the exudation of various compounds which are influenced and modified by environmental factors. Buckwheat root exudate and root system response to neighbouring plants (buckwheat or redroot pigweed) and how ...
Çağla Görkem Eroğlu, Alexandra A. Bennett, Teresa Steininger-Mairinger, Stephan Hann, Markus Puschenreiter, Judith Wirth, Aurélie Gfeller   +6 more
doaj   +1 more source