Results 41 to 50 of about 1,643,891 (268)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Precision separation of thick double-sided microlens arrays via stepwise immersion ultrafast laser modification and controlled thermal stress

Materials & Design
Double-sided microlens arrays (DSMLAs) are integral to large field of view imaging and precise beam shaping in compact optical systems. However, separating thick DSMLAs with precision and efficiency remains challenging, particularly due to laser ...
Qiuchen Xie, Tianfeng Zhou, Zhikang Zhou, Xuan Cui, Zihao Zeng, Peng Liu   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Effects of finite material size on axion-magnon conversion

Journal of High Energy Physics
Magnetic materials are particularly favorable targets for detecting axions interacting with electrons because the collective excitation of electron spins, the magnon, can be excited through the axion-magnon conversion process.
So Chigusa, Asuka Ito, Kazunori Nakayama, Volodymyr Takhistov   +3 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Understanding the Chronologies of England’s Field Systems

, 2021
The chapter presents the outcomes from a project funded by Historic England to collate and analyse scientific dates for field systems in England. The project identified 393 scientific dates from more than 120 excavated field systems. The analysis provides a constructive critique of fieldscape chronologies and recommends methodological improvements and ...
Johnston, R., May, R., McOmish, D.
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Latitude Variation of Flux and Impact Angle of Asteroid Collisions with Earth and the Moon

The Planetary Science Journal, 2021
Flux and impact angles were calculated for asteroid collisions with Earth and the Moon, using the latest population models for the distribution of near-Earth objects (NEOs) and precession models to determine the impact probabilities.
Darrel Robertson, Petr Pokorný, Mikael Granvik, Lorien Wheeler, Clemens Rumpf   +4 more
doaj   +1 more source