Results 51 to 60 of about 1,643,891 (268)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Calculation of core loss and copper loss in amorphous/nanocrystalline core-based high-frequency transformer

AIP Advances, 2016
Amorphous and nanocrystalline alloys are now widely used for the cores of high-frequency transformers, and Litz-wire is commonly used as the windings, while it is difficult to calculate the resistance accurately.
Xiaojing Liu, Youhua Wang, Jianguo Zhu, Youguang Guo, Gang Lei, Chengcheng Liu   +5 more
doaj   +1 more source

A production throughput forecasting system in an automated hard disk drive test operation using GRNN

Journal of Industrial Engineering and Management, 2016
Purpose: The goal of this paper is to develop a pragmatic system of a production throughput forecasting system for an automated test operation in a hard drive manufacturing plant.
Nara Samattapapong, Nitin Afzulpurkar
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Dual-mode varifocal Moiré metalens for quantitative phase and edge-enhanced imaging

Nanophotonics
Transport-of-intensity equation (TIE) as a noninterference method for quantitative phase imaging (QPI) has broad applications in micrographic imaging and optical metrology.
Lian Yi, Liu Yongqi, Cheng Dewen, Chi Cheng, Bao Yanjun, Wang Yongtian   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Dynamic optical chirality based on liquid-crystal-embedded nano-cilia photonic structures

Nature Communications
Compared to natural chiral molecules, artificial chiral photonic structures offer stronger chiroptical responses. However, the remarkable optical properties of most chiral structures are fixed upon fabrication, limiting their applications in scenarios ...
Sufan Li, Yiheng Zhang, Yang Wang, Guiyuan Cao, Qinghua Liang, Xiaochen Zhang, Haozhe Sun, Yongyue Zhang, Zhiyu Wang, Xing Liu, Peng Chen, Han Lin, Baohua Jia, Yan-Qing Lu, Jiafang Li   +14 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Minimising the Kullback–Leibler Divergence for Model Selection in Distributed Nonlinear Systems

Entropy, 2018
The Kullback–Leibler (KL) divergence is a fundamental measure of information geometry that is used in a variety of contexts in artificial intelligence.
Oliver M. Cliff, Mikhail Prokopenko, Robert Fitch   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source