Results 71 to 80 of about 2,242,763 (316)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Minimising the Kullback–Leibler Divergence for Model Selection in Distributed Nonlinear Systems

Entropy, 2018
The Kullback–Leibler (KL) divergence is a fundamental measure of information geometry that is used in a variety of contexts in artificial intelligence.
Oliver M. Cliff, Mikhail Prokopenko, Robert Fitch   +2 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Border field/apparatuses.

, 2019
Through both our trans-disciplinary practice and one specific project based in and across the Irish border with the UK, we discover, occupy and create (alternate) field conditions of various kinds.
Vardy, Sam, McCloskey, Paula
core  

Movement behaviour of the carabid beetle Pterostichus melanarius in crops and at a habitat interface explains patterns of population redistribution in the field

, 2014
Animals may respond to habitat quality and habitat edges and these responses may affect their distribution between habitats. We studied the movement behaviour of a ground-dwelling generalist predator, the carabid beetle Pterostichus melanarius (Illiger).
Allema, Dr. A.B. (Wageningen University, Leerstoelgroep Farming Systems Ecology) DAI=info:eu-repo/dai/nl/334083516
core   +1 more source

Silicon nano-kirigami with controlled plastic, elastic and hysteretic deformations

Nature Communications
Nano-kirigami, inspired by the art of paper cutting and folding, offers a promising approach to three-dimensional (3D) nanomanufacturing by simply transforming two-dimensional (2D) precursors into complex 3D architectures. Here we report a profound study
Qinghua Liang, Zhiguang Liu, Yu Han, Shang Chen, Haozhe Sun, Yingying Chen, Yongyue Zhang, Meihua Niu, Chongrui Li, Yang Wang, Ke Jin, Yongtian Wang, Yugui Yao, Juan Liu, Jiafang Li   +14 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Prevalence and factors associated with pre-diabetes and diabetes mellitus in Kenya: results from a national survey

BMC Public Health, 2018
Background Diabetes Mellitus is one of the four major non-communicable diseases causing about 4 million deaths in 2017. By 2040, low income countries are projected to experience 92% increase in mortality due to diabetes.
Shukri F Mohamed, Martin Mwangi, Martin K Mutua, Joseph Kibachio, Abubakar Hussein, Zachary Ndegwa, Scholastica Owondo, Gershim Asiki, Catherine Kyobutungi   +8 more
doaj   +1 more source