Results 261 to 270 of about 581,117 (305)
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Pharmacology of systemic analgesics
Best Practice & Research Clinical Anaesthesiology, 2002Systemic administration of analgesic drugs is still the most widely used method for providing pain relief in acute painful situations. Opioids may be selected on the basis of their physicochemical characteristics and their diffusion index to the brain.
Camu, Fréderic, Vanlersberghe, C.
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Systems Biology and Pharmacology
Clinical Pharmacology & Therapeutics, 2010Drug action depends not only on the direct consequences of the interaction between the drug and its target but also on other consequences within the complex physiological system that is the human body. The National Institute of General Medical Sciences (NIGMS) has brought together investigators from the emerging field of systems biology with ...
J M, Berg, M E, Rogers, P M, Lyster
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Pharmacometabolomics: Implications for Clinical Pharmacology and Systems Pharmacology
Clinical Pharmacology & Therapeutics, 2013Metabolomics, the study of metabolism at an "omic" level, has the potential to transform our understanding of mechanisms of drug action and the molecular basis for variation in drug response. It is now possible to define metabolic signatures of drug exposure that can identify pathways involved in both drug efficacy and adverse drug reactions.
R, Kaddurah-Daouk, R M, Weinshilboum
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PHARMACOLOGY OF THE KALLIKREIN–KININ SYSTEM
Pharmacological Research, 1997---
REGOLI, Domenico +2 more
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Pharmacology of the vestibular system
Current Opinion in Neurology, 2000In the past year significant advances have been made in our understanding of the neurochemistry and neuropharmacology of the peripheral and central vestibular systems. The recognition of the central importance of excitatory amino acids and their receptors at the level of the hair cells, vestibular nerve and vestibular nucleus has progressed further ...
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Quantitative systems pharmacology: a promising approach for translational pharmacology
Drug Discovery Today: Technologies, 2016Biopharmaceutical companies have increasingly been exploring Quantitative Systems Pharmacology (QSP) as a potential avenue to address current challenges in drug development. In this paper, we discuss the application of QSP modeling approaches to address challenges in the translational of preclinical findings to the clinic, a high risk area of drug ...
K, Gadkar +3 more
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Explore pharmacological mechanism of glycyrrhizin based on systems pharmacology
China Journal of Chinese Materia Medica, 2016To explore the pharmacological mechanism of glycyrrhizin with series methods of systems pharmacology, main diseases related to glycyrrhizin were obtained by text mining tool; and the target proteins of glycyrrhizin were obtained via the database of Polysearch and PubChem. Then, the target proteins interaction network of glycyrrhizin was built using the
Yu-Kun, Zhao +8 more
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Pharmacology and behavioral pharmacology of the mesocortical dopamine system
Progress in Neurobiology, 2001The prefrontal cortex (PFC) has long been known to be involved in the mediation of complex behavioral responses. Considerable research efforts are directed towards refining the knowledge about the function of this brain area and the role it plays in cognitive performance and behavioral output.
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Pharmacology of pain processing systems
Zeitschrift f�r Rheumatologie, 1998Integration of nociceptive signaling comprises peripheral, spinal, and supraspinal sites of the nervous system. Various excitatory or inhibitory neurotransmitter and--modulator systems participate in pain processing and modulation. Chronic pain states are associated with functional and structural alterations of nociceptive pathways.
Schadrack, J., Zieglgänsberger, W.
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