Results 271 to 280 of about 581,117 (305)
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Pharmacometrics and Systems Pharmacology 2030
Clinical Pharmacology & Therapeutics, 2019In 2012, a new journal was launched from the ASCPT family, CPT: Pharmacometrics and Systems Pharmacology (PSP) as both quantitative system pharmacology (QSP) and pharmacometrics were growing fields in pharmacology, drug development, and drug use. In this Perspective, the present editors and associate editors of PSP want to share their strategic vision ...
France, Mentré +9 more
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Pharmacology of descending control systems
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1985Abstract In the cat there is no convincing evidence that a particular compound mediates a supraspinal control of spinal transmission of nociceptive information. There is good evidence that opioid peptides are released segmentally in response to nociceptive input to the spinal cord and that this acts to inhibit motoneurons and to ...
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Clinical Pharmacology of Systemic Corticosteroids
Annual Review of Pharmacology and Toxicology, 1977of the inflammatory manif estations of rheumatoid arthritis after the admin istration of cortisone. In 1971, Christy (1) estimated that more than 5 million patients were treated with corticosteroids yearly. From this enormous experience and from a massive literature, concepts have evolved regarding the safe and effective use of these agents.
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Clinical pharmacology of systemic antidotes
Clinical Pharmacology & Therapeutics, 1961This review is restricted to those agents which are effective by systemic rather than local action. Thus, there are to be found discussions of chelating agents, narcotic antagonists, anticholinesterase antidotes, cyanide antidotes, fluoroacetate antidotes, bemegride, and agents useful in digitalis, methemoglobin, chlorpromazine, amphetamine ...
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Systems Pharmacology: An Overview
2016Systems pharmacology has evolved from a discipline that focuses on drug action at the organ level to a discipline that combines traditional pharmacokinetic and pharmacodynamic modeling with recent systems biology approaches. The integration of high-throughput data technologies with computational data analysis and modeling offers new opportunities to ...
Marc R. Birtwistle +6 more
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Pharmacology of the Cholinergic System
1995As long ago as 1931 Hess suggested that the parasympathetic or cholinergic system was involved in sleep promotion. Since then, the evidence for a role of the cholinergic system in the regulation of wakefulness (W) and sleep, particularly rapid eye movement (REM) sleep, has increased enormously and at the same time has become more specific.
G. Tononi, O. Pompeiano
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Reinforcement learning for systems pharmacology-oriented and personalized drug design
Expert Opinion on Drug Discovery, 2022Yang Liu, Lei Xie
exaly
A framework for simplification of quantitative systems pharmacology models in clinical pharmacology
British Journal of Clinical Pharmacology, 2022Abdallah Derbalah +2 more
exaly