Results 91 to 100 of about 2,984,717 (307)

Focusing on optimality for the translation of precision medicine

Journal of Clinical and Translational Science, 2022
Anna R. Kahkoska, Kristen Hassmiller Lich, Michael R. Kosorok   +2 more
doaj   +1 more source

Systems mapping of multilevel factors contributing to dental caries in adolescents

Frontiers in Oral Health
Dental caries is a prevalent chronic disease among adolescents. Caries activity increases significantly during adolescence due to an increase in susceptible tooth surfaces, immature permanent tooth enamel, independence in pursuing self-care, and a ...
Fatima Sadjadpour, Niyousha Hosseinichimeh, Bhavna T. Pahel, Sara S. Metcalf   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Systems and human science, for safety, security, and dependability : seleced papers of the 1st International Symposium SSR2003, Osaka, Japan, November 2003 /

, 2005
Our society keeps growing with a large number of complicated machines and systems, while we are spending our diverse lives. The number of aged people has been increasing in the society.
Arai, Tatsuo., Keisoku Jidō Seigyo Gakkai (Japan), International Symposium on Systems and Human Science(1st :2003 :Osaka University), Makino, Kazuhisa., Ōsaka Daigaku., Yamamoto, Shigeru, Robotics Society of Japan.   +6 more
core  

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Chain Communication Systems

, 2014
This article elaborates on large-scale chain communication between autonomous organisations and professionals focused on solving social problems. We introduce a dynamic chain concept combined with a special chain information strategy that may help us to ...
Software Systems, Grijpink, Jan, Grijpink, J.H.A.M., Sub Algemeen Software Systems   +3 more
core  

Comparing complex perspectives on obesity drivers: action‐driven communities and evidence‐oriented experts

Obesity Science & Practice, 2018
Summary Introduction The Foresight obesity map represents an expert‐developed systems map describing the complex drivers of obesity. Recently, community‐led causal loop diagrams have been developed to support community‐based obesity prevention ...
J. McGlashan, J. Hayward, A. Brown, B. Owen, L. Millar, M. Johnstone, D. Creighton, S. Allender   +7 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Computationally Modeling the Physiologic Impact of the Ratio of Fats to Carbohydrates in the Diet on Intake Among Metabolically Healthy Adults

Current Developments in Nutrition
Background: When it comes to how effectively a diet can help reduce or maintain body weight, a key question is how that diet affects a person’s hunger, satiety, and subsequent eating.
Marie F Martinez, Jessie Heneghan, Colleen Weatherwax, Timothy H Moran, Britt Burton-Freeman, Kavya Velmurugan, José M Ordovás, Sarah M Bartsch, Tej D Shah, Jennifer Lee, Sarah L Booth, Samantha Kleinberg, Kevin L Chin, Kayla de la Haye, Alexis Dibbs, Sheryl A Scannell, Bruce Y Lee   +16 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source