Results 101 to 110 of about 2,984,717 (307)
Systemic Cognition: A Few Epistemological Clarifications
SystemsSystemic cognition combines the humanities and social sciences with systems science to support a unified field, Human Systems Integration (HSI). It draws on complementary, sometimes conflicting, fields of research, including phenomenology, positivism ...
Guy André Boy
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Why We Stay Stuck: A Complex Conceptual Systems Theory for Wicked Problems
SystemsWicked problems spanning systemic educational inequities, economic disparities, and environmental sustainability resist most traditional change efforts.
Jonan Phillip Donaldson
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
, 2009 Science has been under attack in the last thirty years, and recently a number of prominent scientists have been busy fighting back. Here, an argument is presented that the `science wars' stem from an unreasonably strict adherence to the reductive method ...
Kitto, Kirsty
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Integrating systems science perspective across various STEM literacies
, 2020 Over the last decade various science literacy frameworks have been developed, including the Ocean Literacy Framework, The Essential Principles of Climate Literacy, or Energy Literacy: Essential Principles and Fundamental Concepts for Energy Education ...
Storksdieck, Martin
core
A research agenda for malaria eradication: health systems and operational research. [PDF]
, 2011 Health systems research and development is needed to support the global malaria eradication agenda. In this paper, we (the malERA Consultative Group on Health Systems and Operational Research) focus on the health systems needs of the elimination phase of
The maIera Consultative Group on Health Systems Operational Rese, +2 more
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
HCI research at the institute of systems science
, 1991 10.1145/108844.109014Conference on Human Factors in Computing Systems - Proceedings483 ...
Waterworth, J.A., Motiwalla, J.
core +1 more source