Results 111 to 120 of about 2,984,717 (307)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
, 2000 This paper undertakes a theoretical investigation of the 'learning' aspect of science as opposed to the 'knowledge' aspect. The practical background of the paper is in agricultural systems research – an area of science that can be characterised as ...
Alrøe, Hugo Fjelsted
core
HOLISTIC NATURAL SYSTEMS - DESIGN & STEERING: NEW SCIENCE FOR INDIVIDUAL SYSTEMS
, 2023 Great societies and their cultures grow from small beginnings, some becoming imperiled by challenges of their own making, as ours has with our ever-growing power causing conflicts both with ourselves and nature. It is now becoming possible to compare the
Henshaw, Jessie Lydia
core
Giving Science Innovation Systems a 'Nudge'
Technology Innovation Management Review, 2019 In this article we consider the role that contextual factors play in science innovation systems – that is, the choice architecture, that influences the orientation and outcomes of publicly-funded research.
Kirsty de Jong +4 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
The science of science: From the perspective of complex systems
Physics Reports, 2017 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Zeng, An +6 more
openaire +3 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2013 Information systems as an artefact-oriented discipline require a strong interaction between researchers, developers and users regarding design of, development of, and the study of the use of digital artefacts in social settings.
Lind, Mikael, +3 more
core +1 more source
A query suggestion workflow for life science IR-systems [PDF]
, 2014 Summary Information Retrieval (IR) plays a central role in the exploration and interpretation of integrated biological datasets that represent the heterogeneous ecosystem of life sciences. Here, keyword based query systems are popular user interfaces. In
Hassani-Pak, K. +11 more
core +1 more source