Results 121 to 130 of about 2,984,717 (307)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Human Performance in Information Transmission: Part I: General Remarks; and Part II: Sequential Tasks (Overlearned Activities)

, 1955
Control Systems Laboratory changed its name to Coordinated Science LaboratoryDepartment of the Army (Signal Corps and Ordnance Corps), Department of the Navy (Office of Naval Research), and Department of the Air Force (Office of Scientific Research, Air ...
Staff and Consultants, Bio-Systems Group
core  

Housing as a social determinant of health: System perspectives from lived experience, policy and evidence

Journal of Critical Public Health
Poor housing is a recognised contributor to poor health but, like many ‘wicked’ issues, policy intervention has proved challenging. This paper considers efforts to use systems mapping, a core systems science tool, to support housing policy teams in ...
Lisa Garnham, Katherine Smith, Ellen Stewart, Clementine Hill O'Connor   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Social Pedagogy and School Community Preventing Bullying in Schools and Dealing with Diversity: Two Sides of the Same Coin

International Journal of Social Pedagogy, 2015
This paper presents a social pedagogical research programme that has been carried out during the years of economic crisis in Greece. It focuses on preventing bullying in schools, primarily by dealing with personal beliefs about diversity as well as by ...
doaj   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Design science: a case study in information systems re-engineering

, 2009
Recently, many organisations have become aware of the limitations of their legacy systems to adapt to new technical requirements. Trends towards e-commerce applications, platform independence, reusability of pre-built components, capacity for ...
Valverde, Raul, Cater-Steel, Aileen, Toleman, Mark   +2 more
core  

REASON CP: a systems-based framework for clinical reasoning to support participation across the lifespan in childhood-onset neurodisability

Frontiers in Public Health
Cerebral palsy, a common example of childhood-onset neurodisability (COND), is a heterogeneous neurodevelopmental condition characterized by complexity and variability across individuals.
Margaret Mayston, Sarah Foley, Kelly Reynolds, Willeke Walsh, Gillian Saloojee   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source