Results 121 to 130 of about 37,129,814 (295)

Why We Stay Stuck: A Complex Conceptual Systems Theory for Wicked Problems

Systems
Wicked problems spanning systemic educational inequities, economic disparities, and environmental sustainability resist most traditional change efforts.
Jonan Phillip Donaldson
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Computationally Modeling the Physiologic Impact of the Ratio of Fats to Carbohydrates in the Diet on Intake Among Metabolically Healthy Adults

Current Developments in Nutrition
Background: When it comes to how effectively a diet can help reduce or maintain body weight, a key question is how that diet affects a person’s hunger, satiety, and subsequent eating.
Marie F Martinez, Jessie Heneghan, Colleen Weatherwax, Timothy H Moran, Britt Burton-Freeman, Kavya Velmurugan, José M Ordovás, Sarah M Bartsch, Tej D Shah, Jennifer Lee, Sarah L Booth, Samantha Kleinberg, Kevin L Chin, Kayla de la Haye, Alexis Dibbs, Sheryl A Scannell, Bruce Y Lee   +16 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Digital and Computational Methods for Sustainable Urban Transitions: A Critical Narrative Review Through Urban Design

Land
The accelerating convergence of urbanization, climate change, and digital transformation is reshaping how cities are conceived, designed, and managed. This critical narrative review asks one central question: how can newly emerging digital capabilities ...
Andreas L. Savvides
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Proceedings of the Arizona-Nevada Academy of Science, Volume 01 (1960)

, 1960
FIRST ANNUAL MEETING / April 9, 1960 / Arizona-Sonora Desert Museum and University of Arizona / Tucson, ArizonaThis volume is part of the Arizona-Nevada Academy of Science collections.
Arizona-Nevada Academy of Science
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Proceedings of the Arizona-Nevada Academy of Science, Volume 05 (1968)

, 1968
FIFTH ANNUAL MEETING / May 10-11, 1968 / Northern Arizona University / Flagstaff, ArizonaThis volume is part of the Arizona-Nevada Academy of Science collections.
Arizona-Nevada Academy of Science
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source