Results 141 to 150 of about 2,984,717 (307)

Human Performance in Information Transmission: Part IV: Flash Recognition of Familiar Displays [PDF]

open access: yes, 1956
Made available in DSpace on 2015-04-06T20:44:36Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) B1-69.pdf: 67977871 bytes, checksum: 85069567717ae6833deb7ba468e6c493 (MD5) Previous issue date: 1956-
Staff and Consultants, Bio-Systems Group
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Gaming science innovations to integrate health systems science into medical education and practice

open access: yes, 2018
Earla J White,1 Joy H Lewis,1 Lise McCoy2 1Department of Public Health, School of Osteopathic Medicine in Arizona, A.T. Still University, Mesa, AZ, USA; 2Department of Medical Humanities and Healthcare Leadership, School of Osteopathic Medicine in ...
White EJ, McCoy L, Lewis JH
core  

Perspectives Workshop: Science of design: High-impact requirements for software-intensive systems. Executive summary

open access: yes, 2022
2 S.This document gives a brief motivation for and summary of the perspectives workshop "Science of Design - High-Impact Requirements for Software-Intensive Systems".
Jarke, M., Mylopoulos, J., Lyytinen, K.
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Laboratory Systems [PDF]

open access: yes
Our Mission: To strengthen the nation\ue2\u20ac\u2122s clinical and public health laboratory system by continually improving quality and safety, informatics and data science, and workforce competencyOur Work\ue2\u20ac\ua2 Quality and safety.

core  

Towards Critical Design Science Research [PDF]

open access: yes, 2017
We argue for combining the forces of Design Science Research (DSR) and the critical research traditions. In Information Systems (IS) research, design science research (DSR) has gained momentum during the past decade, while critical research has ...
Iivari, Netta, Kuutti, Kari
core  

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

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