Results 171 to 180 of about 37,129,814 (295)

Systems science approaches to cardiovascular disease prevention and management in the era of COVID-19: A Humpty-Dumpty dilemma? [PDF]

Prog Cardiovasc Dis, 2023
Pronk NP, Mabry PL, Bond S, Arena R, Faghy MA.   +4 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Participatory systems science modeling with coalitions identifies common dynamics that drive health trends and disparities in seven communities across the United States. [PDF]

BMC Public Health
Calancie L, Moore TR, Appel JM, Burns C, Brown C, Fair ML, Fisher E, Greer YD, Hennessy E, Kress M, Ihedigbo K, Medina A, Morales M, Nevels D, Plattner S, Rivers S, Thomson CA, Turner LD, Ulseth M, Warriner C, Werner K, Wills S, Economos CD.   +22 more
europepmc   +1 more source

Using simulation modelling and systems science to help contain COVID-19: A systematic review. [PDF]

Syst Res Behav Sci, 2022
Zhang W, Liu S, Osgood N, Zhu H, Qian Y, Jia P.   +5 more
europepmc   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Bridging Theory and Practice: a qualitative study on electronic charting and health systems science in Korean medicine education in alignment with KAS2022. [PDF]

J Pharmacopuncture
Lee WT, Kim BM, Choi HY, Kim SK, Park SE.   +4 more
europepmc   +1 more source

Implementation of simulation-based health systems science modules for resident physicians. [PDF]

BMC Med Educ, 2022
Li L, Ray JM, Bathgate M, Kulp W, Cron J, Huot SJ, Wong AH.   +6 more
europepmc   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Transdisciplinary perspectives for health systems science. [PDF]

Npj Health Syst
Bian J, Liu N, Overgaard SM, Padman R, Steel PAD, Tiase V, Whitcomb CA, Zhang J, Zhang Y.   +8 more
europepmc   +1 more source

Building Culturally Centered System Dynamics Logic Models for the Brown Buttabean Motivation Organization: Protocol for a Systems Science Approach. [PDF]

JMIR Res Protoc, 2023
Savila F, Harding T, Swinburn B, Bagg W, Letele D, Laban F, Goodyear-Smith F.   +6 more
europepmc   +1 more source