Results 191 to 200 of about 37,129,814 (295)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Governance of Indigenous data in open earth systems science. [PDF]

Nat Commun
Jennings L, Jones K, Taitingfong R, Martinez A, David-Chavez D, Alegado Rʻ, Tofighi-Niaki A, Maldonado J, Thomas B, Dye D, Weber J, Spellman KV, Ketchum S, Duerr R, Johnson N, Balch J, Carroll SR.   +16 more
europepmc   +1 more source

Highlighting a curricular need: Uncertainty, COVID-19, and health systems science. [PDF]

Health Sci Rep, 2021
Papanagnou D, Jaffe R, Ziring D.
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Addressing the Increasing Rate of Caesarean Sections in an Australian Healthcare System: A Systems Science Approach to Identify Stakeholder Perspectives. [PDF]

Nurs Health Sci
O'Halloran S, Perlen S, Chapman A, Luba S, Dawson SL, Cusworth R, Alston L, Vasilevski V, Sweet L, Vuillermin P, Hutchinson AM, Pregnancy Research and Translation Ecosystem Investigator group.   +11 more
europepmc   +1 more source

Postdigital Applied Systems Science Education: Toward an Integral Framework, Curriculum, and Pedagogy. [PDF]

Postdigit Sci Educ, 2022
Hogan M, Harney O.
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

A systems science approach to identifying data gaps in national data sources on adolescent suicidal ideation and suicide attempt in the United States. [PDF]

BMC Public Health, 2023
Giabbanelli PJ, Rice KL, Nataraj N, Brown MM, Harper CR.   +4 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Health systems science and systems thinking: qualitative evaluation of preclinical medical student reflections in a role-play simulation game. [PDF]

BMC Med Educ
Dang TKC, Park KH, Lee ST.
europepmc   +1 more source