Results 181 to 190 of about 2,984,717 (307)

Design and implementation of a health systems science curriculum at a large teaching hospital. [PDF]

BMC Med Educ, 2022
Harcher E, Fakolade A, Gordon D, Nedorost S.   +3 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Dryland Systems Program Science and Implementation Meeting

, 2016
Dryland Systems Program Science and Implementation ...
Vlek, Paul
core  

Early exposure to a primary care course: a co-created transformative approach in health systems science. [PDF]

Med Educ Online
Suppawittaya P, Khowsathit P, Leelasithorn S, Sitthirat P, Kaewkamjornchai P.   +4 more
europepmc   +1 more source

Systems science approaches to cardiovascular disease prevention and management in the era of COVID-19: A Humpty-Dumpty dilemma? [PDF]

Prog Cardiovasc Dis, 2023
Pronk NP, Mabry PL, Bond S, Arena R, Faghy MA.   +4 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Controlling privacy in recommender systems

, 2014
Recommender systems involve an inherent trade-off between accuracy of recommendations and the extent to which users are willing to release information about their preferences.
Jaakkola, Tommi S., Xin, Yu
core  

Lessons from complex systems science for AI governance. [PDF]

Patterns (N Y)
Kolt N, Shur-Ofry M, Cohen R.
europepmc   +1 more source

Using simulation modelling and systems science to help contain COVID-19: A systematic review. [PDF]

Syst Res Behav Sci, 2022
Zhang W, Liu S, Osgood N, Zhu H, Qian Y, Jia P.   +5 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source