Results 211 to 220 of about 2,984,717 (307)

Postdigital Applied Systems Science Education: Toward an Integral Framework, Curriculum, and Pedagogy. [PDF]

Postdigit Sci Educ, 2022
Hogan M, Harney O.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Health systems science and systems thinking: qualitative evaluation of preclinical medical student reflections in a role-play simulation game. [PDF]

BMC Med Educ
Dang TKC, Park KH, Lee ST.
europepmc   +1 more source

A systems science approach to identifying data gaps in national data sources on adolescent suicidal ideation and suicide attempt in the United States. [PDF]

BMC Public Health, 2023
Giabbanelli PJ, Rice KL, Nataraj N, Brown MM, Harper CR.   +4 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Identification of Health Systems Science in a Problem-Based Learning Clinical Reasoning Exercise. [PDF]

Med Sci Educ, 2022
Rowland-Seymour A, Mann D, Singh MK, Padrino SL, Wilson-Delfosse AL.   +4 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Tsunami Evacuation Plan for the Hatfield Marine Science Center - Newport, OR

This report outlines the current evacuation plan for Oregon State University's Hatfield Marine Science Center and makes recommendations for enhancements and changes.
Hunter-Zaworski, Katherine, Intelligent Transportation Systems Class   +1 more
core  

Systems-Based Practice and Health Systems Science in Graduate Medical Education: Recommendations for Embracing This Critical Core Competency. [PDF]

J Grad Med Educ
DeWaters AL, Cooney R, Gonzalo JD, Gorski V, Goss E, Kim JG, Skae CC.   +6 more
europepmc   +1 more source

Understanding the Influence of Community-Level Determinants on Children's Social and Emotional Well-Being: A Systems Science and Participatory Approach. [PDF]

Int J Environ Res Public Health, 2022
Poon BT, Atchison C, Kwan A.
europepmc   +1 more source