Results 211 to 220 of about 37,129,814 (295)

Understanding Perinatal Mental Health: A Systems Science Approach to Identify Common Drivers and Opportunities for Intervention. [PDF]

Int J Ment Health Nurs
O'Halloran SA, Cusworth R, Sunder P, Alston L, Vasilevski V, Dawson SL, Sweet L, Chapman A, Vuillermin P, Sominsky L, Pregnancy Research and Translation Ecosystem Investigator Group.   +10 more
europepmc   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Assessment of students' ability to represent determinants of health and health systems science content on concept maps in a pre-clerkship curriculum. [PDF]

BMC Med Educ
Tripp T, Hoffman M, Miller M, Josephs JS.   +3 more
europepmc   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Population Health and Systems Science: Medical Student Feedback on a Novel Approach That Follows a National Curricular Framework. [PDF]

J Med Educ Curric Dev
Levin J, Beck Dallaghan G, Atwood C, Casanova V, Ball C, Byrd T, Elueze E, Kennedy M, Nessim D, Pendergrass P, Tiruneh Y.   +10 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Simulated retail food environments: A literature review of systems science approaches to advance equity in access to healthy diets. [PDF]

Obes Rev
Mui Y, Winkler MR, Hunt SL, Gittelsohn J, Tracy M.   +4 more
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Building a health systems science bridge between medical school and the clinical learning environment via a pilot faculty development cohort program. [PDF]

BMC Med Educ
Harendt SM, Allison-Jones L, Rudd MJ, Karp NE, Parker SH, Whicker SA.   +5 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source