Results 101 to 110 of about 33,318,051 (318)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Nonlinear Min-Cost-Pursued Route-Swapping Dynamic System
Discrete Dynamics in Nature and Society, 2013 This study proposes a nonlinear min-cost-pursued swapping dynamic (NMSD) system to model the evolution of selfish routing games on traffic network where travelers only swap from previous costly routes to the least costly ones. NMSD is a rational behavior
Wenyi Zhang +3 more
doaj +1 more source
Forecasting Promotional Sales Within the Neighbourhood
IEEE Access, 2019 Promotions are a widely used strategy to engage consumers and as such, retailers dedicate immense effort and resources to their planning and forecasting.
Carlos Aguilar-Palacios +2 more
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Discrete Dynamics in Nature and Society, 2012 The operational efficiency and safety of pedestrian flows at intersections is an important aspect of urban traffic. Particularly, conflicts between pedestrians and vehicles in crosswalk are one of the most influential factors for intersection safety ...
Xiaomeng Li +3 more
doaj +1 more source
IEEE Access, 2018 Location selection for urban distribution centers (DCs) is vital in saving distribution cost and reducing the negative externalities arising from freight transportation.
Shilong Li, Zhenlin Wei, Ailing Huang
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
An Improved Deep Learning Model for Traffic Crash Prediction
Journal of Advanced Transportation, 2018 Machine-learning technology powers many aspects of modern society. Compared to the conventional machine learning techniques that were limited in processing natural data in the raw form, deep learning allows computational models to learn representations ...
Chunjiao Dong +3 more
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source