Results 151 to 160 of about 33,318,051 (318)

Judicial Response to Ecological Environment Risk in China-From the Perspective of Social Systems Theory. [PDF]

Int J Environ Res Public Health, 2022
Sang T, Liu P, Zhao L.
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Experiences and Support Needs of Parents of Children with Strabismus: A Family Systems Theory Perspective. [PDF]

J Multidiscip Healthc
Zhao BB, Wang H, Luo N, Zhang ZZ.
europepmc   +1 more source

Time-resolved circular dichroism of excitonic systems: theory and experiment on an exemplary squaraine polymer. [PDF]

Chem Sci, 2023
Ress L, Malý P, Landgraf JB, Lindorfer D, Hofer M, Selby J, Lambert C, Renger T, Brixner T.   +8 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Multifaceted determinants of social-emotional problems in preschool children in Sweden: An ecological systems theory approach. [PDF]

SSM Popul Health, 2023
Vaezghasemi M, Vogt T, Lindkvist M, Pulkki-Brännström AM, Richter Sundberg L, Lundahl L, Silfverdal SA, Feldman I, Ivarsson A.   +8 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Dynamical systems theory as an organizing principle for single-cell biology. [PDF]

NPJ Syst Biol Appl
Islam S, Bhattacharya S.
europepmc   +1 more source

Reinvigorating an Academy of Medical Educators Using Ecological Systems Theory. [PDF]

Cureus, 2022
Zwemer E, Chen F, Beck Dallaghan GL, Shenvi C, Wilson L, Martinelli SM, Resnick-Kahle M, Crowner J, Joyner BL, Westervelt L, Jordan JM, Chuang A, Shaheen A.   +12 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source