Results 291 to 300 of about 323,783 (333)

Systems toxicology

2021
Systems toxicology, a branch of toxicology that studies chemical effects on biological systems, presents exciting knowledge discovery challenges for the information researcher. The exponential increase in availability of genomic and proteomic data in this domain needs to be matched with increasingly sophisticated network analysis approaches.
Kaushal D. Desai, Xiaohua Hu
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Proteomics in systems toxicology

2021
Proteins are the ultimate product of gene expression. As they hinge between gene transcription and phenotype, they offer a more realistic perspective of toxicopathic effects, responses and even susceptibility to insult than targeting genes and mRNAs while dodging some inter-individual variability that hinders measuring downstream endpoints like ...
Carolina, Madeira, Pedro M, Costa
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Quantitative systems toxicology

Nature Reviews Drug Discovery
Reliable prediction and prevention of adverse drug reactions (ADRs) remains a key challenge in the development of new medicines. Advanced mathematical and computational modelling approaches, which incorporate cutting-edge mechanistic understanding of ADRs in concert with systematically collected data addressing knowledge gaps, are integral components ...
Goldring, Christopher E., Russomanno, Giusy, Pin, Carmen, Trairatphisan, Panuwat, Beattie, Kylie A., Fisher, Ciaran P., Pinero, Janet, Brennan, Richard J., Clausznitzer, Diana, Copple, Ian M., de Kok, Theo M., Duckworth, Carrie A., Furlong, Laura I., Fuzi, Barbara, Gabor, Attila, Gall, Louis, Hengstler, Jan, Hermjakob, Henning, Hunter, Fiona, Jennen, Danyel, Koskinen, Mikko, Kunnen, Steven J., Lammens, Lieve, Lobentanzer, Sebastian, Mohr, Marcel, Passini, Elisa, Pritchard, D. Mark, Malik-Sheriff, Rahuman S., Rodriguez, Blanca, Rossman, Eric I., Saez-Rodriguez, Julio, Schmidt, Friedemann, Sison-Young, Rowena, Soininen, Inari, Turner, Sean, van de Water, Bob, van Hasselt, Johan G. C., Venezia, Filippo, Willy, Jeffrey A., Leishman, Derek J., Stevens, James L., Laplanche, Loic   +41 more
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Systems biology approaches for toxicology

Journal of Applied Toxicology, 2007
AbstractSystems biology/toxicology involves the iterative and integrative study of perturbations by chemicals and other stressors of gene and protein expression that are linked firmly to toxicological outcome. In this review, the value of systems biology to enhance the understanding of complex biological processes such as neurodegeneration in the ...
William, Slikker, Merle G, Paule, Linnzi K M, Wright, Tucker A, Patterson, Cheng, Wang   +4 more
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Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology

Expert Review of Proteomics, 2005
Toxicogenomics can facilitate the identification and characterization of toxicity, as illustrated in this review. Toxicogenomics, the application of the functional genomics technologies (transcriptomics, proteomics and metabolomics) in toxicology enables the study of adverse effects of xenobiotic substances in relation to structure and activity of the ...
Heijne, W.H.M., Kienhuis, A.S., Ommen, B. vnn, Stierum, R.H., Groten, J.P.   +4 more
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Toxicology case data reporting system

Forensic Science International, 1988
A computerized system has been organized to serve the toxicology sections of seven R.C.M.P. laboratories across Canada. Scientists may view and retrieve information concerning drugs and drug combinations, blood and liver drug concentrations, etc. from cases of sudden death or impaired driving which were analyzed in the laboratories.
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Toward an integrative systems toxicology

Pharmacogenomics, 2004
10.1517/14622416.5.8.1163 © Assessing toxicity is among the most ancient and important of human endeavors. Long before the taming of fire or the advent of tool use, humankind was confronted with a most basic problem of existence: what to ingest. Today, toxicology impacts every facet of our lives – from the food, supplements and therapeutics that we ...
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In Vitro Toxicology Systems

2014
Addresses toxicity testing, in vitro, in a variety of different human system ...
Leonard, Martin O, Limonciel, A.V.S., Jennings, P.   +2 more
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The evolving role of investigative toxicology in the pharmaceutical industry

Nature Reviews Drug Discovery, 2023
Francois Pognan, , Richard J Weaver
exaly  

Toxicology of Motor Systems

1995
There is no shortage of toxic factors that have been proposed as aetiological agents in motor neuron disease. Of exogenous origin lead, mercury (elemental and organic) selenium and manganese are most cited (Tandan and Bradley 1985). The incidence of the amyotrophic lateral sclerosis (motor neuron disease)-parkinsonism-dementia complex (ALS-PD) of Guam ...
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