Results 71 to 80 of about 140,566 (249)
RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis
Advanced Science, EarlyView.Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao +28 more
wiley +1 more source
LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1
Advanced Science, EarlyView.LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li +12 more
wiley +1 more source
Radiographic study on the tibial insertion of the posterior cruciate ligament
Revista Brasileira de Ortopedia, 2015 OBJECTIVE: To establish the radiographic distances from posterior cruciate ligament (PCL) tibial insertions centers to the lateral and medial tibial cortex in the anteroposterior view, and from these centers to the PCL facet most proximal point on the ...
Julio Cesar Gali +3 more
doaj +1 more source
A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes
Advanced Science, EarlyView.We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen +13 more
wiley +1 more source
New design of a patello-femoral prosthesis [PDF]
, 2010 Este artigo descreve as patologias do joelho passíveis de serem tratadas com próteses patelofemorais bem como as deficiências mais comuns das próteses disponíveis no mercado e propõe o desenvolvimento de uma prótese com novo design que venha a ...
Cameron, Eliomar
core
Use of gastrocnemius muscle on treatment of infected injuries of the knee [PDF]
, 2009 OBJETIVO: Avaliar prospectivamente o emprego do retalho do músculo gastrocnêmio no tratamento de lesões infectadas do joelho. MÉDOTOS: foram operados 12 pacientes, onze do sexo masculino, com idade variando de 19 a 78 anos, média de 55 anos.
MATTAR JUNIOR, Rames +5 more
core +2 more sources
Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis
Advanced Science, EarlyView.This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou +23 more
wiley +1 more source
Artrodese do tornozelo : bindicações e técnicas cirúrgicas [PDF]
, 2014 Trabalho final de mestrado integrado em Medicina (Ortopedia), apresentado á Faculdade de Medicina da Universidade de CoimbraA artrodese do tornozelo consiste na fusão da articulação com a intenção de conseguir o alívio/supressão da dor e a recuperação ...
Silva, Vítor Gonçalo Bentinho
core
The value of the image diagnosis methods in the evaluation of reactions/stress fractures [PDF]
, 2003 UNIFESP Departamento de Diagnóstico por ImagemUNIFESPUNIFESP, Depto.
Aihara, André Yui +2 more
core +3 more sources
Advanced Science, EarlyView.This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen +12 more
wiley +1 more source