Results 81 to 90 of about 140,566 (249)

Bifidobacterium Pseudolongum‐Derived Acetate Attenuates Acute Pancreatitis Through GPR43‐Mediated Suppression of M1 Macrophage Polarization

Advanced Science, EarlyView.
The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan, Xueyang Li, Cong He, Pan Zheng, Yaoyu Zou, Qi Zhu, Xin Li, Jie Liang, Junmin Yang, Li Zhang, Yuman Ye, Jianhua Wan, Huajing Ke, Jianping Liu, Nonghua Lu, Nianshuang Li, Yin Zhu   +16 more
wiley   +1 more source

no Município de Alfredo Marcondes (Estado de São Paulo), Formação Adamantina (Turoniano-Santoniano), Bacia Bauru. [PDF]

, 2007
Sauropod dinosaurs (Titanosauria) remains were collected in Upper Cretaceous sandstones, at Alfredo Marcondes site, Adamantina Formation, São Paulo state. These fossils comprise a fragmentary right femur and a proximal portion of a right tibia. The femur
Carlos Roberto dos Anjos Candeiro, Lílian Paglarelli Bergqvist, Rodrigo Pinto Fernandes de Azevedo   +2 more
core  

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

Adaptações biomecânicas do osso cortical de camundongos submetidos à três diferentes modalidades de exercício [PDF]

Acta Ortopédica Brasileira, 2013
OBJETIVO: Comparar os efeitos adaptativos de três modalidades de exercício de impacto reduzido nas adaptações mecânicas do osso cortical. MÉTODOS: Vinte e quatro camundongos machos, espécie Balb/c (25±3g), foram divididos aleatoriamente em quatro grupos (
Fernando Tadeu Trevisan Frajacomo, Maurício José Falcai, Cleverson Rodrigues Fernandes, Antonio Carlos Shimano, Sérgio Britto Garcia   +4 more
doaj   +2 more sources

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source

EXPERIMENT AND SIMULATION ON MECHANICAL PROPERTIES OF OSTEOPOROTIC MOUSE BONE (MT)

Jixie qiangdu, 2023
The osteoporosis model of mouse tibia was established based on castration, and the effect of osteoporosis on the mechanical properties of tibia was investigated. The two-dimensional sections of mouse tibia were obtained by Micro-CT. The three-dimensional
ZHAO Qing, YIN ZiYang, ZHOU Wen, REN GuanLin, KUANG ChunMei, HU Cong, ZHOU ChangJiang   +6 more
doaj  

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

Faunas mamalógicas do sítio pós-orientalizante do Cabeço Redondo (Sobral da Adiça, Moura) [PDF]

, 2013
Resultados da análise dos restos faunísticos recuperados em 2011, na escavação arqueológica do sítio do Cabeço Redondo (Moura, Beja), cuja cronologia aponta para o século V a.C.
Cardoso, João Luís, Soares, Rui Manuel Gusmão Monge   +1 more
core  

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

Tratamento de osteonecrose da tíbia induzida por corticosteroides – descompressão e Haste intramedular de tíbia - relato de caso

Journal of the Foot & Ankle
A osteonecrose associada ao uso de corticosteroides é a segunda causa mais frequente de osteonecrose não traumática. A maioria das evidências concentra-se na cabeça femoral, havendo escassez de dados sobre acometimento metadiafisário e sobre estratégias
Tânia Szejnfeld Mann
doaj   +1 more source