Results 121 to 130 of about 57,741 (199)

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

Ancient DNA from the Upper Paleolithic mammoth ivory of Hohle Fels, Germany. [PDF]

Sci Rep
Moreland KN, Wolf S, Drucker DG, Weingarten A, Reiter E, Spyrou MA, Conard NJ, Posth C.   +7 more
europepmc   +1 more source

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

Transfer learning for T-cell response prediction. [PDF]

BMC Bioinformatics
Stadelmaier J, Malone B, Eggeling R.
europepmc   +1 more source

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Adult-Onset Multisystem Langerhans Cell Histiocytosis: Atypical Skeletal and Endocrine Manifestations. [PDF]

Cureus
Hacker P, Benignus C, Frauenfeld L, Traub F.   +3 more
europepmc   +1 more source

The Story(line) So Far: A Survey on Storyline Visualization

Computer Graphics Forum, EarlyView.
Abstract Storyline visualizations model narratives as temporal networks, using x‐monotone lines to represent entities and their interactions over time. This technique offers an intuitive way to reveal structural patterns over time, such as character co‐occurrence and narrative flow.
S. Di Bartolomeo, A. Dobler, V. Filipov, M. Nöllenburg, H. Ehlers   +4 more
wiley   +1 more source

Commentary: Yin and Yang of MAITs in HCC: balancing type 1 vs. type 17 signaling. [PDF]

Cell Mol Immunol
Beyer S, Ruf B.
europepmc   +1 more source

Similar or Different? Configurations of Authenticity Across Museum Types

Curator: The Museum Journal, EarlyView.
ABSTRACT Authenticity is traditionally regarded as playing a crucial role in museums, science centers, and memorials. However, despite this fact, authenticity has very different meanings in different (institutional) settings. This complicates shared communications across museum practices.
S. Schwan, S. Bahnsen, C. Eschenfelder, B. Garsoffky, P. Gerjets, M. Gorman, C. Hampp, L. Kampschulte, O. Köller, C. Kuchler, A. M. Land‐Zandstra, S. Moser, T. Moussouri, P. Pierroux, C. Sichau, I. Specht, M. Storksdieck, M. Xanthoudaki, D. Lewalter   +18 more
wiley   +1 more source

Covalent drug rescue of multiple p53 mutants by stabilizing vinyl sulfone fragments hints to a specific refolding mechanism for R282W. [PDF]

Protein Sci
Stahlecker J, Klett T, Spiegel R, Schwer M, Mier F, Aldea S, Masberg B, Lämmerhofer M, Stehle T, Böckler FM.   +9 more
europepmc   +1 more source