Results 51 to 60 of about 57,741 (199)

Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure

Clinical Pharmacology &Therapeutics, EarlyView.
This study investigated genetic determinants of the pharmacokinetics of the CYP2C8 index drugs repaglinide and gemfibrozil, and their interaction in healthy participants. Sequencing data from a study with montelukast revealed a novel functional CYP2C8 allele (rs2071426, CYP2C8*19), predicted to create an intronic splice donor site.
Anssi J. H. Mykkänen, Päivi Hirvensalo, Kathrin Klein, Dorota Kaminska, Markus Grube, Tuija Tapaninen, Johanna I. Kiiski, Mikko Neuvonen, Ville T. Männistö, Jussi Pihlajamäki, Mladen Tzvetkov, Matthias Schwab, Aleksi Tornio, Janne T. Backman, Mikko Niemi   +14 more
wiley   +1 more source

Mosaic activation of the zebrafish hsp70l heat shock promoter: Implications for interpreting transgenes

Developmental Dynamics, EarlyView.
Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley   +1 more source

Left ventricular function improvement during angiotensin receptor–neprilysin inhibitor treatment in a cohort of HFrEF/HFmrEF patients

ESC Heart Failure, Volume 12, Issue 2, Page 1151-1165, April 2025.
Prediction of LVEF improvement in patients with HFrEF and HFmrEF following treatment with Sacubitril/Valsartan. Workflow of this study investigating the functional capacity improvement in response to Sacubitrail/Valsartsan in a real‐world scenario of heart failure treatment.
Florian Appenzeller, Tobias Harm, Manuel Sigle, Parwez Aidery, Klaus‐Peter Kreisselmeier, Livia Baas, Andreas Goldschmied, Meinrad Paul Gawaz, Karin Anne Lydia Müller   +8 more
wiley   +1 more source

Review: Steffen Wippel, Wirtschaft, Politik und Raum: Territoriale und regionale Prozesse in der westlichen Sahara (2012) Buchbesprechung: Steffen Wippel, Wirtschaft, Politik und Raum: Territoriale und regionale Prozesse in der westlichen Sahara (2012)

Africa Spectrum, 2013
Review of the monograph:Steffen Wippel, Wirtschaft, Politik und Raum: Territoriale und regionale Prozesse in der westlichen Sahara, 2 volumes, Berlin/Tübingen: Verlag Hans Schiler, 2012, ISBN 9783899303674, xiv + 1,438 pagesBesprechung der Monographie ...
Laurence Marfaing
doaj  

T. Matějčková, Gibt es eine Welt in Hegels Phänomenologie des Geistes?

Reflexe, 2019
Book review: Tereza Matějčková, Gibt es eine Welt in Hegels Phänomenologie des Geistes?Tübingen (Mohr Siebeck) 2018, 342 str.
Martin Vrabec
doaj   +1 more source

Chiral HPLC Separation of Phosphonothrixin and Phosphonate Derivatives and Electronic Circular Dichroism Characterization of the Isolated Enantiomers

ELECTROPHORESIS, EarlyView.
Natural compound phosphonothrixin's herbicidal activity resides exclusively in its (S)‐enantiomer, yet existing enantioselective syntheses are cumbersome, and direct chiral LC separation is hampered by the compound's high polarity, lack of aromatic groups, and metal chelation–induced peak tailing.
Mirna Maalouf, Maximilian Knab, Leon Gessner, Marc Engelhardt, Stella Friedrich, Harald Gross, Frank Boeckler, Chambers C. Hughes, Michael Lämmerhofer   +8 more
wiley   +1 more source

Comparison of volume‐ and surface‐based magnetic resonance imaging morphometry algorithms in the detection of focal cortical dysplasia

Epilepsia, EarlyView.
Abstract Objective Detection of focal cortical dysplasia (FCD) remains a major challenge in presurgical epilepsy diagnostics. Magnetic resonance imaging (MRI) morphometry increasingly improves lesion detection and postsurgical outcomes. The volume‐based Morphometric Analysis Program, version 2018 (MAP18) with integrated artificial neural network and ...
Lara Bücheler, Marco Reisert, Theo Demerath, Florian Mayer, Christian Moeller, Joshua Reß, Yiwen Li Hegner, Dirk‐Matthias Altenmüller, Victoria San Antonio‐Arce, Christian Scheiwe, Mukesch Shah, Jürgen Beck, Soroush Doostkam, Thomas Bast, Bernhard J. Steinhoff, Andreas Schulze‐Bonhage, Horst Urbach, Marcel Heers   +17 more
wiley   +1 more source

Standards for Computational Methods in Drug Design and Discovery: Simplified Guidance for Authors and Reviewers

Drug Design, Development and Therapy
Tamer M Ibrahim,1,2 Muzammal Hussain,3,4 Frank M Boeckler5,6 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt; 2Center for Informatics Science (CIS), School of Information Technology and ...
Ibrahim TM, Hussain M, Boeckler FM
doaj  

Ansätze der Familienfreundlichkeit an der Medizinischen Fakultät Tübingen (MFT) [Approaches to family-friendliness at the Medical Faculty of Tübingen (MFT)]

GMS Zeitschrift für Medizinische Ausbildung, 2012
[english] The feminization of the medical profession, demographic change with an impending shortage of physicians, Generation Y - these issues are new challenges for medical schools in terms of their social responsibility and the training of the next ...
Holderried, Friederike, Keil-Pilz, Regina, Zipfel, Stephan   +2 more
doaj   +1 more source

Fritz Scheffer Under National Socialism: Assessing His Political Involvement

Journal of Plant Nutrition and Soil Science, EarlyView.
ABSTRACT Aims This article examines the role of soil scientist Fritz Scheffer (1899–1979) under National Socialism and offers a critical assessment of his scientific, institutional, and political positioning between 1933 and 1945. It asks how Scheffer shaped his career within the tension between disciplinary specialization, political expectations, and ...
Jan Arend
wiley   +1 more source