Results 61 to 70 of about 313,523 (292)

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

Stellar laboratories. V. The Xe VI ultraviolet spectrum and the xenon abundance in the hot DO-type white dwarf RE0503-289 [PDF]

, 2015
For the spectral analysis of spectra of hot stars with a high resolution and high signal-to-noise ratio (S/N), advanced non-local thermodynamic equilibrium (NLTE) model atmospheres are mandatory.
Gallardo, M., Hoyer, D., Quinet, P., Raineri, M., Rauch, T.   +4 more
core   +1 more source

Gesteht! [PDF]

Rechtsgeschichte - Legal History, 2002
Rezensiertes Werk:Bernd Rüthers, Geschönte Geschichten – Geschonte Biographien. Sozialisationskohorten in Wendeliteraturen.
Marie Theres Fögen
doaj   +1 more source

Individualized Atrophy‐Based Prediction of Dementia Progression in Familial Frontotemporal Lobar Degeneration With Bayesian Linear Mixed‐Effects Modeling

Annals of Neurology, EarlyView.
Objective Age of symptom onset is highly variable in familial frontotemporal lobar degeneration (f‐FTLD). Accurate prediction of onset would inform clinical management and trial enrollment. Prior studies indicate that individualized maps of brain atrophy can predict conversion to dementia in f‐FTLD.
Shubir Dutt, Dana Leichter, Yann Cobigo, Amy Wolf, John Kornak, Annie Clark, Lucy L. Russell, Arabella Bouzigues, David M. Cash, Martina Bocchetta, Molly Olzinski, Brian Appleby, Ece Bayram, Barbara Borroni, Andrea Bozoki, Chris R. Butler, David Clark, Rhian S. Convery, R. Ryan Darby, Alexandre de Mendonça, Bradford Dickerson, Kimiko Domoto‐Reilly, Simon Ducharme, Eve Ferry‐Bolder, Elizabeth Finger, Phoebe H. Foster, Douglas R. Galasko, Daniela Galimberti, Alexander Gerhard, Nupur Ghoshal, Caroline Graff, Neill Graff‐Radford, Ian M. Grant, Chadwick M. Hales, Lawrence S. Honig, Ging‐Yuek Hsiung, Edward D. Huey, David Irwin, Lize C. Jiskoot, Walter Kremers, Justin Y. Kwan, Robert Laforce, Isabelle Le Ber, Gabriel C. Léger, Johannes Levin, Irene Litvan, Ian R. Mackenzie, Mario Masellis, Mario F. Mendez, Fermin Moreno, Chiadi Onyike, Markus Otto, Belen Pascual, Peter Pressman, Rosa Rademakers, Eliana Marisa Ramos, Aaron Ritter, Erik D. Roberson, James B. Rowe, Raquel Sanchez‐Valle, Isabel Santana, Harro Seelaar, Allison Snyder, Sandro Sorbi, Matthis Synofzik, Maria Carmela Tartaglia, Pietro Tiraboschi, John C. van Swieten, Marijne Vandebergh, Rik Vandenberghe, Hilary W. Heuer, Bruce L. Miller, William W. Seeley, Maria Luisa Gorno‐Tempini, Joel H. Kramer, Leah Forsberg, Kejal Kantarci, Bradley F. Boeve, Adam L. Boxer, Jonathan D. Rohrer, Howard J. Rosen, Adam M. Staffaroni, FTD Prevention Initiative (FPI) investigators   +82 more
wiley   +1 more source

Ulrike Müssig, Die europäische Verfassungsdiskussion des 18. Jahrhunderts, 2008

Czasopismo Prawno-Historyczne, 2010
Recenzja: Ulrike Müssig, Die europäische Verfassungsdiskussion des 18. Jahrhunderts.
Anna Tarnowska
doaj   +1 more source

Aufklärung des Wirkmechanismus der Synthetase: Das Dimer der Pyrrolysyl‐tRNA‐Synthetase nutzt sekundäre Bindungsstellen in der Zelle

Angewandte Chemie, EarlyView.
Das Dimer der Pyrrolysyl‐tRNA‐Synthetase zeigt im katalytischen Zyklus einen alternierenden Wirkmodus seiner Monomere, der durch die Belegung sekundärer Bindungsstellen an den Intermonomer‐Grenzflächen außerhalb der katalytischen Bindungsstelle realisiert wird.
Jessica Dröden, Christoph Globisch, Eliane Landwehr, Theresa S. Braun, Daniel Summerer, Christine Peter, Malte Drescher   +6 more
wiley   +1 more source

Barbaric, Damir (2015). Chora. Über das zweite Prinzip Platons. Attempto Verlag, Tübingen

Archai: Revista de Estudos sobre as Origens do Pensamento Ocidental, 2017
Herkert, Felix (2017). Rezension: Barbaric, Damir (2015). Chora. Über das zweite Prinzip Platons. Attempto Verlag, Tübingen.
Felix Herkert
doaj   +1 more source

Unraveling Synthetase's Mode of Action: The Pyrrolysyl‐tRNA Synthetase Dimer Uses Secondary Binding Sites in the Cell

Angewandte Chemie International Edition, EarlyView.
The pyrrolysyl‐tRNA synthetase dimer exhibits an alternating mode of action of its monomers within its catalytic cycle, which is realized upon occupation of secondary binding sites located at the intermonomer interfaces outside the catalytic binding site.
Jessica Dröden, Christoph Globisch, Eliane Landwehr, Theresa S. Braun, Daniel Summerer, Christine Peter, Malte Drescher   +6 more
wiley   +1 more source

Combined PET/MRI: from Status Quo to Status Go. Summary Report of the Fifth International Workshop on PET/MR Imaging; February 15–19, 2016; Tübingen, Germany

Molecular Imaging and Biology, 2016
This article provides a collaborative perspective of the discussions and conclusions from the fifth international workshop of combined positron emission tomorgraphy (PET)/magnetic resonance imaging (MRI) that was held in Tübingen, Germany, from February ...
Dale L. Bailey, Bernd J. Pichler, B. Gückel, Henryk Barthel, Ambros J. Beer, R. M. Botnar, Robert J. Gillies, Vicky Goh, M. Gotthardt, Rodney J. Hicks, R. Lanzenberger, C. L. Fougère, M. Lentschig, S. Nekolla, T. Niederdraenk, Konstantin Nikolaou, J. Nuyts, D. Olego, K. Riklund, A. Signore, M. Schäfers, Vesna Sossi, M. Suminski, P. Veit-Haibach, L. Umutlu, M. Wissmeyer, Thomas Beyer   +26 more
semanticscholar   +1 more source

Herausforderung Curriculumentwicklung: ein konzeptioneller Ansatz zur Professionalisierung

Zeitschrift für Hochschulentwicklung, 2014
Die Politik hat mit dem Qualitätspakt Lehre auf die Desiderate der Bologna-Reform reagiert. In diesem Rahmen werden an der Universität Tübingen innovative Curriculumentwicklungen gefördert und wissenschaftlich begleitet.
Carolin Niethammer, Ines Koglin-Heß, Sabine Digel, Josef Schrader   +3 more
doaj   +1 more source