Results 211 to 220 of about 383,521 (254)

T-2 toxin is hydroxylated by chicken CYP3A37

Food and Chemical Toxicology, 2013
T-2 toxin (T-2) is an acute toxic trichothecene mycotoxin produced mainly by Fusarium species, detected in many crops including oats, wheat and barley, in animal feed and food. It is important to know the metabolic pathway and kinetics of T-2 in food animals given that T-2 can cause serious adverse effects on human health.
Yiyang, Yuan, Xiaojie, Zhou, Jiannan, Yang, Mei, Li, Xinghui, Qiu   +4 more
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Review of neurotoxicity of T-2 toxin

Mycotoxin Research
T-2 toxin is a representative trichothecene that is widely detected in corn, wheat and other grain feeds. T-2 toxin has stable physical and chemical properties, making it difficult to remove from food and feed. Hence, T-2 toxin has become an unavoidable pollutant in food for humans and animals.
Youshuang Wang, Bo Wang, Peilin Wang, Zeao Hua, Shanshan Zhang, Xuebing Wang, Xu Yang, Cong Zhang   +7 more
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Improved preparation of T-2 toxin-protein conjugates

Toxicon, 1988
T-2 toxin (T-2) was converted into T-2 hemisuccinate (T-2 HS), T-2 hemiglutarate (T-2 HG) and T-2 hemiphthalate (T-2 HP), and conjugated with bovine serum albumin (BSA), ovalbumin (OVA) and keyhole limpet haemocyanin (KLH) using carbodiimide under various conditions.
K, Ohtani, O, Kawamura, Y, Ueno
openaire   +2 more sources

Characterisation of hemolysis induced by T-2 toxin

Biochimica et Biophysica Acta (BBA) - General Subjects, 1985
The erythrocyte constitutes a good model system for the study of membrane-associated toxicity events caused by the trichothecene mycotoxin, T-2. This study confirms that T-2 has a direct lytic effect on erythrocytes. Lysis of guinea pig red cells requires approx. 10(10) molecules/cell and reaches plateau values after 4-6 h.
M I, Gyongyossy-Issa, V, Khanna, G G, Khachatourians   +2 more
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T-2 toxin inhibits mitochondrial function in yeast

Biochemical and Biophysical Research Communications, 1988
T-2 toxin inhibits oxygen consumption of whole cells and purified mitochondria of Saccharomyces cerevisiae. Inhibition of mitochondrial respiration is not relieved by 2, 4-dinitrophenol, indicating that T-2 toxin inhibits mitochondrial function at the level of the electron transport chain. T-2 toxin inhibition of state 3 respiration (with succinate) is
H, Koshinsky, S, Honour, G, Khachatourians   +2 more
openaire   +2 more sources

T-2 toxin effect on cultured myocardial cells

Toxicology Letters, 1986
Beat rate, contractility and viability of cultured myocardial cells perfused with solutions containing various concentrations of T-2 toxin were studied. While doses below 50 micrograms/ml had no immediate effect, those above 250 micrograms/ml decreased beat rate and amplitude.
R, Yarom, Y, Hasin, S, Raz, Y, Shimoni, R, Fixler, B, Yagen   +5 more
openaire   +2 more sources

T-2 toxin mycotoxicosis in the guinea-pig

Food and Cosmetics Toxicology, 1978
Summary Purified T-2 toxin dissolved in saline-dimethylsulphoxide (DMSO) 10: 1 (v/v) was administered by gastric intubation in single doses of 1·85, 2·52, 3·45 and 4·66 mg/kg body weight to male guinea-pigs. The acute oral LD 50 in the male guinea-pig was estimated to be 3·06 (2·38–3·93) mg/kg.
D B, DeNicola, A H, Rebar, W W, Carlton, B, Yagen   +3 more
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Hepatic subcellular distribution of [3H]T-2 toxin

Toxicon, 1989
The subcellular distribution of T-2 mycotoxin and its metabolites was studied in isolated rat livers perfused with [3H]T-2 toxin. After a 120-min perfusion, the distribution of radiolabel was to bile 53%, perfusate 38% and liver 7%. Livers were fractionated into mitochondria, endoplasmic reticulum (smooth and rough), plasma membrane and nuclei.
J G, Pace, M R, Watts
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Biosynthesis and preparation of T-2 Toxin, HT-2 Toxin and Neosolantol

Mycotoxin Research, 1987
Biosynthesis of trichothecenes by strains ofF. sporotriahioides KF 9 6 and KF 530 was performed on rice as a medium. Three toxins in significant amounts were produced, with yield: T-2 toxin 0.7g from 600g of drv culture, being the highest of the three metabolites, HT-2 toxin 0.06g an Neosolaniol 0.015g.
M, Kostecki, H, Jeleń, P, Gliński, J, Chełkowski   +3 more
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A monoclonal antibody to T-2 toxin

Letters in Applied Microbiology, 1987
A specific, high affinity monoclonal antibody to T-2 toxin of Fusarium has been produced. The monoclonal antibody was conjugated to horse-radish peroxidase and employed to develop a direct competitive enzyme-linked immunosorbent assay (ELISA) for the toxin. The sensitivity of the ELISA was 10 ng/ml with a working range up to 500 ng/ml.
I. A. GOODBRAND, W. H. STIMSON, I. E. SMITH   +2 more
openaire   +1 more source