Results 211 to 220 of about 407,843 (257)
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Journal of the American Veterinary Medical Association, 1973
SUMMARY Fusarium tricinctum is consistently the most toxigenic fungus isolated from moldy corn in low-temperature storage. Isolants of this fungus produce T-2 toxin, diacetoxyscirpenol, and a butenolide. The acute oral ld50 of T-2 toxin is approximately 4 mg./kg. of body weight in swine and rats and 6.5 mg./kg. of body weight in rainbow trout.
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SUMMARY Fusarium tricinctum is consistently the most toxigenic fungus isolated from moldy corn in low-temperature storage. Isolants of this fungus produce T-2 toxin, diacetoxyscirpenol, and a butenolide. The acute oral ld50 of T-2 toxin is approximately 4 mg./kg. of body weight in swine and rats and 6.5 mg./kg. of body weight in rainbow trout.
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Review of neurotoxicity of T-2 toxin
Mycotoxin ResearchT-2 toxin is a representative trichothecene that is widely detected in corn, wheat and other grain feeds. T-2 toxin has stable physical and chemical properties, making it difficult to remove from food and feed. Hence, T-2 toxin has become an unavoidable pollutant in food for humans and animals.
Youshuang Wang +7 more
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Chromatographic enzyme immunoassay for T-2 toxin
Journal of Immunological Methods, 1990Both the active ester and maleimide moieties of the cross-linking reagent, N-[(gamma-maleimidobutyryl)oxy]succinimide (GMBS), were found to react with the primary amino groups on ribonuclease (RNase). This largely inactivated RNase towards a polymeric (but not monomeric) substrate.
B A, Warden +5 more
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Cardiomyopathy induced by T-2 toxin in rats
Food and Chemical Toxicology, 2020T-2 toxin, A trichothecenes mycotoxin, is immunotoxic to animals and humans. Although it is highly cardiotoxic, the pathogenesis of cardiomyopathy caused by T-2 toxin is not entirely clear. Hence, in our research, cardiomyopathy was induced by a single injection of T-2 mycotoxin (0.23 mg/kg s.c., 1 LD50) to Wistar rats. The cardiac tissue was carefully
Vesna Jaćević +3 more
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Characterisation of hemolysis induced by T-2 toxin
Biochimica et Biophysica Acta (BBA) - General Subjects, 1985The erythrocyte constitutes a good model system for the study of membrane-associated toxicity events caused by the trichothecene mycotoxin, T-2. This study confirms that T-2 has a direct lytic effect on erythrocytes. Lysis of guinea pig red cells requires approx. 10(10) molecules/cell and reaches plateau values after 4-6 h.
M I, Gyongyossy-Issa +2 more
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The effect of T-2 toxin on human platelets
Toxicology and Applied Pharmacology, 1984Human platelets were incubated with T-2 toxin, the most toxic component of Fusarium fungi, at doses of 5 to 500 micrograms/10(9) platelets. A dose-related inhibition of platelet aggregation and release of dense bodies (these consist mainly of serotonin-containing granules) were observed. A change in membrane permeability in the absence of shape changes
R, Yarom, R, More, A, Eldor, B, Yagen
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Metabolic effects of trichothecene T-2 toxin
Canadian Journal of Physiology and Pharmacology, 1990Cereals and other agricultural products contaminated with trichothecene mycotoxins are unfit for consumption. Until recently, the metabolic effects of T-2 toxin (T-2) were thought to reside in its ability to inhibit protein synthesis. It is now clear that trichothecenes have multiple effects, including inhibition of DNA, RNA, and protein synthesis in ...
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T-2 toxin mycotoxicosis in the guinea-pig
Food and Cosmetics Toxicology, 1978Summary Purified T-2 toxin dissolved in saline-dimethylsulphoxide (DMSO) 10: 1 (v/v) was administered by gastric intubation in single doses of 1·85, 2·52, 3·45 and 4·66 mg/kg body weight to male guinea-pigs. The acute oral LD 50 in the male guinea-pig was estimated to be 3·06 (2·38–3·93) mg/kg.
D B, DeNicola +3 more
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The hemolytic activity of deoxynivalenol and T‐2 toxin
Natural Toxins, 1992AbstractThe hemolytic effects of deoxynivalenol (DON) and T‐2 toxin (T‐2) individually on rat erythrocytes were studied at different concentrations. Sodium azide was used as an enzyme inhibitor to prevent T‐2 toxin metabolism. The concentration of T‐2 was controlled by GC‐MS and no decrease of the toxin was found during the time of the experiment.
A F, Rizzo +3 more
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Analytical and Bioanalytical Chemistry, 2009
The selective enzymatic deacetylation of T-2 toxin to give HT-2 toxin has been investigated in aqueous crude extracts of different cereals and exploited to develop an analytical method for the determination of the sum of T-2 and HT-2 toxins. The method has been validated for the analysis of total T-2 and HT-2 toxins in maize, wheat, and oats, showing ...
Lattanzio VMT, Solfrizzo M, Visconti A
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The selective enzymatic deacetylation of T-2 toxin to give HT-2 toxin has been investigated in aqueous crude extracts of different cereals and exploited to develop an analytical method for the determination of the sum of T-2 and HT-2 toxins. The method has been validated for the analysis of total T-2 and HT-2 toxins in maize, wheat, and oats, showing ...
Lattanzio VMT, Solfrizzo M, Visconti A
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