Results 21 to 30 of about 407,843 (257)
T‐2 Toxin‐Mediated β‐Arrestin‐1 O‐GlcNAcylation Exacerbates Glomerular Podocyte Injury via Regulating Histone Acetylation [PDF]
Advanced ScienceT‐2 toxin causes renal dysfunction with proteinuria and glomerular podocyte damage. This work explores the role of metabolic disorder/reprogramming‐mediated epigenetic modification in the progression of T‐2 toxin‐stimulated podocyte injury.
Tushuai Li +6 more
doaj +2 more sources
Screening, Identification and Action Mechanism of T-2 Toxin-Degrading Strains [PDF]
Shipin Kexue, 2023 The purpose of this study was to obtain microbial strains capable of high-efficiency degradation of T-2 toxin and to investigate their mechanism of action.
MA Yan, SUN Changpo, WANG Jun, DU Wen, LIU Hujun, ZHOU Wenhua, ZHAO Yifan
doaj +1 more source
T-2 Toxin Induces Apoptotic Cell Death and Protective Autophagy in Mouse Microglia BV2 Cells
Journal of Fungi, 2022 T-2 toxin exposure could cause neurotoxicity; however, the precise molecular mechanisms remain unclear. In the present study, we investigated T-2 toxin-induced cytotoxicity and underlying molecular mechanisms using a mouse microglia BV2 cell line.
Tun Sun +4 more
doaj +1 more source
T-2 mycotoxin Induces male germ cell apoptosis by ROS-mediated JNK/p38 MAPK pathway
Ecotoxicology and Environmental Safety, 2023 T-2 mycotoxin, a type A trichothecene toxin that, specifically, causes male and female reproductive toxicity. We evaluated T-2 toxin toxicity in testes from neonatal testes after in vitro tissue cultured.
Won-Young Lee, Hyun-Jung Park
doaj +1 more source
p38 mediates T-2 toxin-induced Leydig cell testosterone synthesis disorder
Ecotoxicology and Environmental Safety, 2023 T-2 toxin is an unavoidable food and feed contaminant that seriously threatens human and animal health. Exposure to T-2 toxin can cause testosterone synthesis disorder in male animals, but the molecular mechanism is still not completely clear.
Xu Yang +9 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2022 T-2 toxin belongs to the trichothecenes group A compound, mainly produced by Fusarium fungi. It has been shown that T-2 toxin could cross the placental barrier and breast milk, thus endangering the health of offspring.
Ruifen Kang +4 more
doaj +1 more source
In Vitro Metabolism of T-2 Toxin [PDF]
Applied Microbiology, 1974 Incubation of T-2 toxin with the 9,000 × g supernatant fluid of both human and bovine liver homogenate resulted in conversion to a single, deacetylated product identified as HT-2 toxin. Metabolism is more rapid in human liver.
R A, Ellison, F N, Kotsonis
openaire +2 more sources
Study on the apoptosis mechanism induced by T-2 toxin. [PDF]
PLoS ONE, 2013 T-2 toxin is known to induce apoptosis in mammalian cells. The mechanism of apoptosis induced by T-2 toxin has been proposed to be linked with oxidative stress and mitochondrial pathway.
Zhenhong Zhuang +3 more
doaj +1 more source
Comparison of Apoptosis and Autophagy in Human Chondrocytes Induced by the T-2 and HT-2 Toxins
Toxins, 2019 In this report, we have investigated the apoptosis and autophagy of chondrocytes induced by the T-2 and HT-2 toxins. The viability of chondrocytes was measured by the MTT assay.
Fang-Fang Yu +4 more
doaj +1 more source
JNK molecule is a toxic target for IPEC-J2 cell barrier damage induced by T-2 toxin
Ecotoxicology and Environmental Safety, 2023 The most prevalent contaminated mycotoxin in feed and grain is T-2 toxin. The T-2 toxin's primary action target is the gut because it is the main organ of absorption.
Fengjuan Chen +6 more
doaj +1 more source