Results 71 to 80 of about 399,149 (348)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The fungal T-2 toxin alters the activation of primary macrophages induced by TLR-agonists resulting in a decrease of the inflammatory response in the pig

Veterinary Research, 2012
T-2 toxin is known to be one of the most toxic trichothecene mycotoxins. Exposure to T-2 toxin induces many hematologic and immunotoxic disorders and is involved in immuno-modulation of the innate immune response.
Seeboth Julie, Solinhac Romain, Oswald Isabelle P, Guzylack-Piriou Laurence   +3 more
doaj   +1 more source

Gene expression in farm poultry under the influence of T-2 toxin and the use of biological preparations

Acta Biomedica Scientifica, 2022
Background. Feed-borne T-2 toxin may inhibit innate immune system function in birds.The aim. To evaluate the effect of T-2 toxin, artificially introduced with feed, on the expression level of a number of immunity-related genes in the tissues of the ...
E. A. Yildirim, A. A. Grozina, L. A. Ilina, V. A. Filippova, G. Y. Laptev, E. S. Ponomareva, A. V. Dubrowin, K. A. Kalitkina, V. V. Molotkov, D. A. Akhmatchin, D. G. Tiurina   +10 more
doaj   +1 more source

Improper Colourings inspired by Hadwiger's Conjecture [PDF]

J. London Math. Society 98.1:129-148, 2018, 2017
Hadwiger's Conjecture asserts that every $K_t$-minor-free graph has a proper $(t-1)$-colouring. We relax the conclusion in Hadwiger's Conjecture via improper colourings. We prove that every $K_t$-minor-free graph is $(2t-2)$-colourable with monochromatic components of order at most $\lceil{\frac12(t-2)}\rceil$.
arxiv   +1 more source

In vitro metabolism of T-2 toxin in rats [PDF]

Applied and Environmental Microbiology, 1980
T-2 toxin was rapidly converted in the 9,000 X g supernatant fraction of rat liver homogenate into HT-2 toxin, T-2 tetraol, and two unknown metabolites designated as TMR-1 and TMR-2. TMR-1 was characterized as 4-deacetylneosolaniol (15-acetoxy-3 alpha, 4 beta, 8 alpha-trihydroxy-12,13-epoxytrichothec-9-ene) by spectroscopic analyses.
S P Swanson, Chester J. Mirocha, Takumi Yoshizawa   +2 more
openaire   +3 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

JNK molecule is a toxic target for IPEC-J2 cell barrier damage induced by T-2 toxin

Ecotoxicology and Environmental Safety, 2023
The most prevalent contaminated mycotoxin in feed and grain is T-2 toxin. The T-2 toxin's primary action target is the gut because it is the main organ of absorption.
Fengjuan Chen, Youshuang Wang, Yunhe Chen, Jiayan Fan, Cong Zhang, Xiuyuan He, Xu Yang   +6 more
doaj  

Coexistence of competing metabolic pathways in well-mixed populations [PDF]

Phys. Rev. E 93, 052401 (2016), 2016
Understanding why strains with different metabolic pathways that compete for a single limiting resource coexist is a challenging issue within a theoretical perspective. Previous investigations rely on mechanisms such as group or spatial structuring to achieve a stable coexistence between competing metabolic strategies.
arxiv   +1 more source

Presence of T-2 and HT-2 toxins in maize

Zbornik Matice srpske za prirodne nauke, 2013
Data on the occurrence of T-2 and HT-2 toxins in maize from Serbia and Europe are very limited. In this study a total of 50 maize samples harvested during September and October 2012 in Serbia were analyzed. Presence of T-2/HT-2 toxins was determined by enzyme-linked immunosorbent assay (ELISA) method.
Elizabet Janic-Hajnal, Jovana Kos, Jasna Mastilovic   +2 more
openaire   +3 more sources

Production of antibody against T-2 toxin [PDF]

Applied and Environmental Microbiology, 1979
Antibody against T-2 toxin was obtained after immunization of rabbits with bovine serum albumin-T-2 hemisuccinate conjugate. The antibody had greatest binding efficiency for T-2 toxin, less efficiency for HT-2, and least for T-2 triol. Cross-reaction of antibody with neosolaniol, T-2 tetraol, and 8-acetyl-neosolaniol was very weak.
C J Mirocha, S Grossman, R D Wei, F S Chu   +3 more
openaire   +3 more sources