Results 71 to 80 of about 383,521 (254)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

T-2 toxin-induced spatial learning and memory impairment in mice via the gut-brain axis and the intervening effects of resveratrol

Ecotoxicology and Environmental Safety
T-2 toxin, classified as a mycotoxin, harms immune and cognitive systems. Recently, an increasing number of studies have focused on the neurotoxic effects of T-2 toxin. However, there is still a need for a better understanding of the molecular mechanisms
Sheng-Quan Su, Gui-Yuan Xiong, Chun-Yan Yao, Xiao-Ling Liu, Yin-Yin Xia, Jin-Yun Long, Xiu-Kuan Li, Liang-Mei Wang, Long Yi, Wu-Wei Xu, Wu-Qiang Lu, Qian-Qian Li, Ting Hu, Hao Liu, Ke-Xue Wang, Peng Luo, Tong-Jian Cai   +16 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Photocatalytic Degradation of T-2 Toxin by Zinc Oxide Nanoparticles [PDF]

Shipin Kexue
In this study, ZnO nanoparticles with high crystallinity and good dispersibility for efficient and green photocatalytic degradation of T-2 toxin were successfully prepared by a green and mild solvent hydrothermal method.
LOU Xiuping, HUANG Qingwen, GUO Wenbo, LIU Xiaojin, WANG Xinyi, NIE Dongxia, HAN Zheng
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Effect of T-2 Toxin in Combination with Vitamin E, Selenium and Mycotoxin Binder on Lipid Peroxide Status and on the Glutathione Redox System in Broiler Chicken

The Journal of Poultry Science, 2006
The effect of T-2 toxin (2.35mg/kg of feed) on lipid peroxidation and on the antioxidant defence system was studied in blood plasma, red blood cells (RBC), liver and spleen of broiler chickens. The influences of antioxidant vitamin E (10.5mg/animal/day)+
Mária Weber, Krisztián Balogh, Márta Erdélyi, Miklós Mézes   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Toxicokinetics of T-2 Toxin, HT-2 Toxin and T-2 Triol after Intravenously Administrated T-2 Toxin in Swine [PDF]

Journal of Animal and Veterinary Advances, 2012
Yong-Xue Sun, Hai-Yan Zhao, Yu-Jing Liu, Zhen-Qing Dai, Bing-Hu Fang   +4 more
openaire   +1 more source

The Effects of T-2 Toxin in Broiler Chickens

Poultry Science, 1973
Abstract T-2 toxin is a mycotoxin produced by several species of Fusarium and small concentrations have been reported earlier to cause severe oral lesions in chickens. Graded concentrations (0, 1, 2, 4, 8, and 16 μg./g.) of dietary T-2 toxin were given to groups of 40 broiler chickens. A total of 240 chicks were used in these experiments.
R D, Wyatt, P B, Hamilton, H R, Burmeister   +2 more
openaire   +2 more sources