Results 171 to 180 of about 10,355,186 (284)

A role for T-bet in metabolic regulation [PDF]

Nature Reviews Immunology, 2013
openaire   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

A combination of proviral and antiviral roles of CD11c- and T-bet-expressing B cells defines parameters of chronic murine gammaherpesvirus infection. [PDF]

mBio
Johansen ER, Bradeen XG, Xie EV, Dittel BN, Leadbetter EA, Tarakanova VL.   +5 more
europepmc   +1 more source

Increased development of T-bet⁺CD11c⁺ B cells predisposes to lupus in females: Analysis in BXD2 mouse and genetic crosses. [PDF]

Clin Immunol, 2023
Sullivan KA, Chapman C, Lu L, Ashbrook DG, Wang Y, Alduraibi FK, Lu C, Sun CW, Liu S, Williams RW, Mountz JD, Hsu HC.   +11 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Know Your ABCs: Discovery, Differentiation, and Targeting of T-Bet+ B Cells. [PDF]

Immunol Rev
Winslow GM, Levack R.
europepmc   +1 more source

Cutting Edge: Optimal Formation of Hepatic Tissue-Resident Memory CD4 T Cells Requires T-bet Regulation of CD18. [PDF]

J Immunol, 2023
Depew CE, Nguyen AT, Franke MC, Calderon J, Sciammas R, McSorley SJ.   +5 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Investigating the Role of T-bet⁺ B Cells (ABCs/DN) in the Immunopathogenesis of Systemic Lupus Erythematosus. [PDF]

Mediterr J Rheumatol, 2023
Sachinidis A, Trachana M, Taparkou A, Gavriilidis G, Verginis P, Psomopoulos F, Adamichou C, Boumpas D, Garyfallos A.   +8 more
europepmc   +1 more source