Results 91 to 100 of about 2,055,767 (301)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

CD4+ T Cell Depletion in Human Immunodeficiency Virus (HIV) Infection: Role of Apoptosis

Viruses, 2011
Human immunodeficiency virus (HIV) infection is principally a mucosal disease and the gastrointestinal (GI) tract is the major site of HIV replication. Loss of CD4+ T cells and systemic immune hyperactivation are the hallmarks of HIV infection.
M. Février, K. Dorgham, A. Rebollo
semanticscholar   +1 more source

Ocrelizumab Depletes CD20+ T Cells in Multiple Sclerosis Patients [PDF]

Cells, 2018
Ocrelizumab, a humanized monoclonal anti-CD20 antibody, has shown pronounced effects in reduction of disease activity in multiple sclerosis (MS) patients and has recently been approved for the treatment of patients with relapsing MS (RMS) and primary progressive MS (PPMS). CD20 is mainly expressed by B cells, but a subset of T cells (CD3+CD20+ T cells)
Stefan Gingele, Thais Langer Jacobus, Franz Felix Konen, Martin W. Hümmert, Kurt-Wolfram Sühs, Philipp Schwenkenbecher, Jonas Ahlbrecht, Nora Möhn, Lars H. Müschen, Lena Bönig, Sascha Alvermann, Reinhold E. Schmidt, Martin Stangel, Roland Jacobs, Thomas Skripuletz   +14 more
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Constitutive CD27/CD70 Interaction Induces Expansion of Effector-Type T Cells and Results in IFNγ-Mediated B Cell Depletion

, 2001
The interaction between the TNF receptor family member CD27 and its ligand CD70 provides a costimulatory signal for T cell expansion. Normally, tightly regulated expression of CD70 ensures the transient availability of this costimulatory signal.
van Oers, Marinus H.J, Hendriks, J., van Lier, René A.W, van Oers, M. H., Hendriks, Jenny, van Lier, R. A., Arens, Ramon, Baars, P. A., Tesselaar, Kiki, Krimpenfort, P., Krimpenfort, Paul, Arens, R., van Schijndel, G. M., Pals, S. T., Pals, Steven T, van Schijndel, Gijs M.W, Tesselaar, K., Baars, Paul A, Borst, Jannie, Borst, J.   +19 more
core   +1 more source

Mechanisms of T-cell Depletion in Tumors and Advances in Clinical Research

Biological Procedures Online
T lymphocytes (T cells) are essential components of the adaptive immune system that play a vital role in identifying and eliminating infected and tumor cells.
Xiangfei Su, Mi Zhang, Hong Zhu, Jingwen Cai, Zhen Wang, Yuewei Xu, Li Wang, Chen Shen, Ming Cai   +8 more
doaj   +1 more source

Bi- and tri-valent T cell engagers deplete tumour-associated macrophages in cancer patient samples

Journal for ImmunoTherapy of Cancer, 2019
Background Tumour-associated macrophages (TAMs) are often implicated in cancer progression but can also exert anti-tumour activities. Selective eradication of cancer-promoting (M2-like) TAM subsets is a highly sought-after goal.
Eleanor M. Scott, Egon J. Jacobus, Brian Lyons, Sally Frost, Joshua D. Freedman, Arthur Dyer, Hena Khalique, William K. Taverner, Alison Carr, Brian R. Champion, Kerry D. Fisher, Len W. Seymour, Margaret R. Duffy   +12 more
doaj   +1 more source

Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1

Journal of Experimental Medicine, 2007
Intrarectal infection between men who have sex with men represents a predominant form of human immunodeficiency virus (HIV) transmission in developed countries.
Zhifeng Sun, Paul W. Denton, J. Estes, Florence A. Othieno, Bangdong L. Wei, A. Wege, Michael W. Melkus, A. Padgett-Thomas, M. Zupancic, A. Haase, J. Victor, Garcia, Correspondence J Victor   +12 more
semanticscholar   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

T cell depletion in paediatric stem cell transplantation

Clinical and Experimental Immunology, 2013
Summary Haematopoietic stem cell transplantation (HSCT) can be a curative procedure for a growing number of paediatric diseases, but as the indications for HSCT grow, so does the need to find suitable stem cell donors. When the preferred option of a genoidentical sibling donor is not available alternative donors, including unrelated ...
C, Booth, P, Veys
openaire   +3 more sources