Results 71 to 80 of about 2,055,767 (301)

Characterization and modulation of anti-αβTCR antibodies and their respective binding sites at the βTCR chain to enrich engineered T cells

Molecular Therapy: Methods & Clinical Development, 2021
T cell engineering strategies offer cures to patients and have entered clinical practice with chimeric antibody-based receptors; αβT cell receptor (αβTCR)-based strategies are, however, lagging behind.
Guido J.J. Kierkels, Eline van Diest, Patricia Hernández-López, Wouter Scheper, Anja C.M. de Bruin, Elselien Frijlink, Tineke Aarts-Riemens, Sanne F.J. van Dooremalen, Dennis X. Beringer, Rimke Oostvogels, Lovro Kramer, Trudy Straetemans, Wolfgang Uckert, Zsolt Sebestyén, Jürgen Kuball   +14 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

GVHD Prophylaxis 2020

Frontiers in Immunology, 2021
Graft-vs. host disease (GVHD), both acute and chronic are among the chief non-relapse complications of allogeneic transplantation which still cause substantial morbidity and mortality despite significant advances in supportive care over the last few ...
Mahasweta Gooptu, Joseph Harry Antin
doaj   +1 more source

Peripheral T Cell Depletion by FTY720 Exacerbates Hypoxic-Ischemic Brain Injury in Neonatal Mice

Frontiers in Immunology, 2018
Hypoxic-ischemic injury to the developing brain remains a major cause of significant long-term morbidity and mortality. Emerging evidence from neonatal brain injury models suggests a detrimental role for peripheral lymphocytes.
J. Herz, C. Köster, Marius Crasmöller, H. Abberger, W. Hansen, U. Felderhoff-Müser, I. Bendix   +6 more
semanticscholar   +1 more source

T-cell depletion: from positive selection to negative depletion in adult patients [PDF]

Bone Marrow Transplantation, 2015
Clinical trials have shown that a strategy for haploidentical transplantation based on the infusion of high numbers of T-cell-depleted hematopoietic progenitor cells and no post-transplant immunosuppression controls graft rejection and GvHD in patients with acute leukemia.
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

T-Cell Subsets Predict Mortality in Malnourished Zambian Adults Initiating Antiretroviral Therapy. [PDF]

, 2015
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedTo estimate the ...
Chisenga, Molly, Suzanne Filteau, Andrew J Prendergast, Joshua Siame (756094), Filteau, S, Prendergast, AJ, Paul Kelly, Siame Joshua, Siame, J, Paul Kelly (95510), Prendergast, Andrew J, Chisenga Caroline C., Filteau Suzanne, Filteau, Suzanne, Siame, Joshua, Molly Chisenga, Suzanne Filteau (132124), Prendergast Andrew J., Chisenga, Caroline C, Chisenga, M, Chisenga Molly, Caroline C. Chisenga (634491), Kelly Paul, Chisenga, CC, Molly Chisenga (756095), Caroline C Chisenga, Andrew J. Prendergast (314511), Joshua Siame, Kelly, Paul, Kelly, P   +29 more
core   +1 more source

Regulatory T cell epitope content in human antibodies decreases during maturation

Frontiers in Immunology
IntroductionAntibody maturation in the lymphoid follicle produces antibodies with improved binding affinity. This process requires iterative rounds of mutation and B cell expansion, supported by T cells that recognize epitopes presented on the B cell’s ...
Andres H. Gutierrez, Frances E. Terry, Amy S. Rosenberg, William D. Martin, Anne S. De Groot   +4 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Limited cholesterol depletion causes aggregation of plasma membrane lipid raftsinducing T cell activation

, 2010
Acute cholesterol depletion is generally associated with decreased or abolished T cell signalling but it can also cause T cell activation. This anomaly has been addressed in Jurkat T cells using progressive cholesterol depletion with methyl-beta ...
Mahammad, Saleemulla, Mahammad, Saleemulla,, Parmryd, Ingela,, Parmryd, Ingela, Dinic, Jelena, Adler, Jeremy, Adler, Jeremy,, Dinic, Jelena,   +7 more
core   +1 more source