Results 51 to 60 of about 2,055,767 (301)
IL-10 and IL-4 in Skin Allograft Survival Induced by T-Cell Depletion plus Deoxyspergualin
Cell Transplantation, 2008 The mechanisms mediating T-cell depletion plus 15-deoxyspergualin (DSG)-induced prolonged allograft survival or tolerance are uncertain. The purpose of this study is to evaluate the role of IL-4 and IL-10 in prolonged allograft survival induced by T-cell
Clement Asiedu +4 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Anti-tumour therapeutic efficacy of OX40L in murine tumour model [PDF]
, 2004 OX40 ligand (OX40L), a member of TNF superfamily, is a co-stimulatory molecule involved in T cell activation. Systemic administration of mOX40L fusion protein significantly inhibited the growth of experimental lung metastasis and subcutaneous (s.c ...
Lynam, J +21 more
core +1 more source
CD4+ T cell depletion in HIV infection: mechanisms of immunological failure
Immunological Reviews, 2013 The hallmark of acquired immunodeficiency syndrome (AIDS) pathogenesis is a progressive depletion of CD4+ T‐cell populations in close association with progressive impairment of cellular immunity and increasing susceptibility to opportunistic infections ...
A. Okoye, L. Picker
semanticscholar +1 more source
Naive T-cell depletion in stem cell transplantation [PDF]
Blood Advances, 2020 Abstract Allogeneic hematopoietic stem cell transplantation (HCT) is curative in many patients with advanced hematopoietic malignancies. Donor T cells not only facilitate engraftment and protect against opportunistic pathogens and residual disease, but can also cause graft-versus-host disease (GVHD), with significant morbidity and ...
openaire +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Dinámica de Linfocitos T en Autoinmunidad. Línea de investigación: Neurociencias clínicas y experimentales [PDF]
, 2013 [esp] La Esclerosis Multiple (EM) se ha considerado una enfermedad autoinmune mediada por linfocitos T con un comportamiento oscilatorio prototípico, caracterizado por la presencia de brotes clínicos. Por tanto, comprender la dinámica de las células del
Martínez Pasamar, Sara
core
Selective depletion of activated T cells: the CD40L-specific antibody experience
, 2004 Blocking the signal that provides co-stimulation to T cells during their encounter with antigen is thought to make T cells anergic or tolerant. Recently, treatments using CD40L-specific antibody, a co-stimulation blocking reagent, in primate transplant ...
Jurcevic, S. +2 more
core +1 more source
Retrovirology, 2016 Early HIV-1 infection is characterized by high levels of HIV-1 replication and substantial CD4 T cell depletion in the intestinal mucosa, intestinal epithelial barrier breakdown, and microbial translocation.
S. Dillon +8 more
semanticscholar +1 more source
Apoptosis and T-cell depletion during feline infectious peritonitis
Journal of Virology, 1996 Cats that have succumbed to feline infectious peritonitis, an immune- mediated disease caused by variants of feline coronaviruses, show apoptosis and T-cell depletion in their lymphoid organs.
B. Haagmans +2 more
semanticscholar +2 more sources